AI Article Synopsis
- - The study investigates the link between apolipoprotein E (APOE) polymorphisms and atherosclerosis affecting multiple vascular areas, as previous risk factors were not clearly established.
- - Researchers analyzed 1,074 patients, finding that those with a specific E3/E4 genotype were less common in multiple-vessel atherosclerosis cases (11.4% vs 17.8%).
- - The results suggest that the ε4 allele is significantly associated with atherosclerosis across multiple vascular beds, highlighting its potential role as a risk factor.
Article Abstract
Background: Atherosclerosis is a systemic disease that can involve multiple vascular beds. The risk factors for atherosclerosis in multiple vascular beds remain unclear. Apolipoprotein E (APOE) is involved in inflammation and lipid deposition in the process of atherosclerosis. The objective of this study was to investigate whether polymorphisms are associated with atherosclerosis in multiple vascular beds.
Methods: A total of 416 patients with atherosclerosis in single vascular bed and 658 patients with atherosclerosis in multiple vascular beds were included. genotypes were detected and the differences of genotypes between the groups were compared. Logistic regression analysis was performed to analyze the relationship between genotypes and atherosclerosis in multiple vascular beds.
Results: E3/E4 genotype frequency was lower in the patients with atherosclerosis in multiple vascular beds than that of patients with atherosclerosis in single vascular bed (11.4% vs 17.8%, =0.004). There was no significant difference in age and gender distribution, proportion of history of smoking, alcohol consumption, hypertension, and diabetes mellitus between the two groups (all >0.05), and among patients with different alleles (all >0.05). Logistic regression analysis indicated that E3/E4 genotype (E3/E4 vs E3/E3: odds ratio (OR) 0.598, 95% confidence interval (CI): 0.419-0.854, =0.005), and ε4 allele (ε4 vs ε3: OR 0.630, 95% CI: 0.444-0.895, =0.010) associated with atherosclerosis in multiple vascular beds.
Conclusion: ε4 allele is associated with atherosclerosis in multiple vascular beds.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11542474 | PMC |
| http://dx.doi.org/10.2147/IJGM.S475771 | DOI Listing |
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