AI Article Synopsis

  • - This study compared the effectiveness of Two-dimensional shear wave elastography (2D-SWE) and transient elastography (TE) in assessing esophagogastric varices risk and histological staging in patients with primary biliary cholangitis (PBC).
  • - Both methods showed similar diagnostic abilities for determining histological stages and detecting esophagogastric varices, with no significant differences in their effectiveness, although 2D-SWE had slightly better accuracy.
  • - The results indicate that 2D-SWE is just as reliable as TE for predicting risks associated with PBC, with minimal impact from laboratory values like transaminases and bilirubin on the measurements.

Article Abstract

Background: This study aimed to compare the diagnostic efficacy of Two-dimensional shear wave elastography (2D-SWE) with that of transient elastography (TE) in predicting the risk of esophagogastric varices and histological staging in patients with primary biliary cholangitis (PBC).

Methods: This single-center prospective study enrolled the patients with PBC diagnosed by liver biopsy following 2D-SWE and TE. Receiver operating characteristic (ROC) curves were constructed for SWE-liver stiffness measurement (LSM) and TE-LSM to assess their diagnostic efficacy for histological staging ≥ stage 2, ≥ stage 3, and = stage 4. The diagnostic efficacy and accuracy of SWE-LSM were compared with those of the Baveno VI criteria for detecting esophagogastric varices. Additionally, the impact of different laboratory parameters on SWE-LSM was analyzed.

Results: We evaluated 77 patients (median age, 52 years (range: 16 - 75 years), 66 females). ROC curves constructed using TE-LSM and SWE-LSM demonstrated similar diagnostic efficacy for histological staging ≥ stage 2 (area under the curve [AUC]: 0.824 vs. 0.823 for TE-LSM and SWE-LSM, respectively, p = 0.9764), ≥ stage 3 (AUC: 0.918 vs. 0.907 for TE-LSM and SWE-LSM, respectively, p = 0.6443), and = stage 4 (AUC: 0.907 vs. 0.902 for TE-LSM and SWE-LSM, respectively, p = 0.8763). Additionally, while there was no significant difference in the diagnostic efficacy between the two methods for detecting esophagogastric varices (Z = 1.516, p = 0.1296), 2D-SWE had a slightly higher diagnostic accuracy than TE (61.8% vs. 76.4%). Transaminases and bilirubin levels had little influence on SWE-LSM.

Conclusion: 2D-SWE exhibited comparable performance to TE in predicting the risk of esophagogastric varices and histological staging.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11542490PMC
http://dx.doi.org/10.1186/s12876-024-03484-5DOI Listing

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