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Overcoming resistance to arginine deprivation therapy using GC7 in pleural mesothelioma.
iScience
January 2025
Centre for Cancer Cell & Molecular Biology, Barts Cancer Institute, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK.
Pleural mesothelioma is a highly chemotherapy-resistant cancer. Approximately 50% of mesotheliomas do not express argininosuccinate synthetase 1 (ASS1), the rate-limiting enzyme in arginine biosynthesis, making arginine depletion with pegylated arginine deiminase (ADI-PEG20) an attractive therapeutic strategy. We investigated whether combinatory treatment composed of ADI-PEG20 and polyamine inhibitors constitutes a promising novel therapeutic strategy to overcome ADI-PEG20 resistance in mesothelioma patients.
View Article and Find Full Text PDFEx-Foods Diets Affect the Fatty Acid Profile of the Abdominal Adipose Tissue Without Significantly Affecting the Plasma Metabolome of Postweaning Piglets.
J Anim Physiol Anim Nutr (Berl)
December 2024
Department of Veterinary Medicine and Animal Sciences, University of Milan, Lodi, Italy.
Food leftovers can be used as alternative feed ingredients for monogastric to replace human-competing feedstuffs, such as cereals, recycle a waste product, reduce the feed-food competition and keep nutrients and energy in the feed-food chain. Among food leftovers, former food products (FFPs) are no more intended for human but still suitable for animal consumption. However, the metabolic impact of FFP has never been investigated.
View Article and Find Full Text PDFPolyamine Seed Priming: A Way to Enhance Stress Tolerance in Plants.
Int J Mol Sci
November 2024
Department of Plant Physiology, Institute of Experimental Biology, Faculty of Biology, Adam Mickiewicz University, Poznań, ul. Uniwersytetu Poznańskiego 6, 61-614 Poznań, Poland.
Polyamines (PAs), such as putrescine, spermine, and spermidine, are bioactive molecules that play a vital role in plant responses to stresses. Although they are frequently applied to achieve higher levels of stress tolerance in plants, their function in seed biology is still not fully understood. PAs have been described in only a limited number of studies as seed priming agents, but most of the data report only the physiological and biochemical PA effects, and only a few reports concern the molecular mechanisms.
View Article and Find Full Text PDFDepression is a stress-associated disorder, and it represents a major global health issue. Its pathophysiology is complex and remains insufficiently understood, with current medications often showing limited efficacy and undesirable side effects. Here, we identify imbalanced polyamine levels and dysregulated autophagy as key components of the acute stress response in humans, and as hallmarks of chronic stress and depressive disorders.
View Article and Find Full Text PDFRoe deer uterine fluid metabolome reveals elevated glycolysis, fatty acid breakdown, and spermidine synthesis upon reactivation from diapause†.
Biol Reprod
November 2024
ETH Zürich, Animal Physiology, Institute of Agricultural Sciences, Universtitätstr. 2, CH-8092 Zurich, Switzerland.
The blastocyst of the European roe deer (Capreolus capreolus) undergoes a period of decelerated growth and limited metabolism. During this period known as embryonic diapause, it floats freely in the uterus encircled by the histotroph. Prior to implantation, reactivation is marked by rapid embryonic growth and conceptus elongation.
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