Background: Gaps persist in the data on diets and on the validity of dietary assessment methods in youth in low-income and middle-income countries (LMICs) due to costs constraints. Although computer vision-assisted dietary assessment tools have been proposed, limited evidence exists on their validity in LMICs.
Objectives: This study aimed to validate FRANI (Food Recognition Assistance and Nudging Insights), a mobile phone application with computer vision-assisted dietary assessment, against weighed records (WRs) and compare with 24-h recalls (24HR), in female youth in Ghana.
Methods: Dietary intake was assessed on 2 nonconsecutive days using FRANI, WR, and 24HR in females aged 18-24 y recruited at the University of Ghana, Accra (n = 64). Equivalence was examined by comparing intake mean ratios (FRANI/WR and 24HR/WR) with error margins of 10%, 15%, and 20%, using mixed-effect regression models adjusting for repeated measures. Agreement between methods was assessed using the concordance correlation coefficient (CCC).
Results: Equivalence for FRANI and WR was found at 10% bound for riboflavin and vitamin B-6 intakes and at 15% bound for protein, fat, calcium, folate, iron, thiamine, vitamin C, and zinc intakes. Energy, fiber, vitamin A, and niacin intakes were equivalent at 20% bound. Comparisons between 24HR and WR found no estimates within a 10% bound. Protein, iron, niacin, riboflavin, and zinc intakes were equivalent at a 15% bound; folate, thiamine, and vitamin B-12 intakes were equivalent at a 20% bound. CCCs between FRANI and WR ranged from 0.45 to 0.74 (mean: 0.60) and between 24HR and WR ranged from 0.48 to 0.76 (mean: 0.63). Omission errors were 15% for FRANI and 22% for 24HR. Intrusion errors were 22% for FRANI and 18% for 24HR.
Conclusions: FRANI-assisted dietary assessment accurately estimates nutrient intake and performed as accurately as 24HR in female youth in Ghana. Although improvements in computer vision-assisted diet assessment are possible, emerging evidence on FRANI suggests its readiness for scale-up.
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http://dx.doi.org/10.1016/j.ajcnut.2024.08.011 | DOI Listing |
Comb Chem High Throughput Screen
January 2025
Department of Endocrinology and Metabolism, the First Affiliated Hospital of Soochow University, 188 Shizi Street, Suzhou, China.
Aims And Objectives: This study aimed to explore the relationship between HERC6- associated immune response and Non-Alcoholic Fatty Liver Disease (NAFLD) and to screen drug candidates for novel treatments.
Materials And Methods: Mendelian Randomization (MR) was performed to test the relationship between a genetically predicted increase in HERC6 expression and the development of NAFLD. A single-cell RNA-seq profile of liver tissue with histological characteristics (GSE168933) was obtained.
Indian Pediatr
January 2025
School of Public Health, DY Patil Deemed to be University, Navi Mumbai, Maharashtra, India.
Objective: To assess the association of dietary fatty acids with asthma in Indian school children.
Methods: Children aged 6-16 years were enrolled from randomly selected urban schools in 10 cities. The International Study on Asthma and Allergies in Childhood Phase III Questionnaire was used to assess the prevalence of asthma.
Clin Transl Med
January 2025
Department of General Surgery (Colorectal Surgery), The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.
Background: Immunotherapy is beneficial for some colorectal cancer (CRC) patients, but immunosuppressive networks limit its effectiveness. Cancer-associatedfibroblasts (CAFs) are significant in immune escape and resistance toimmunotherapy, emphasizing the urgent need for new treatment strategies.
Methods: Flow cytometric, Western blotting, proteomics analysis, analysis of public database data, genetically modified cell line models, T cell coculture, crystal violetstaining, ELISA, metabonomic and clinical tumour samples were conducted to assess the role of EDEM3 in immune escape and itsmolecular mechanisms.
Diabetol Metab Syndr
January 2025
Laboratory of Immunopharmacology, Oswaldo Cruz Institute, Oswaldo Cruz Foundation-Fiocruz, Campus Maré. Centro de Pesquisa, Inovação e Vigilância em Covid-19 e Emergências Sanitárias. Endereço: Av. Brasil, 4036-Bloco 2. Manguinhos, Rio de Janeiro, RJ, CEP 21040-361, Brazil.
Introduction: Metabolic syndrome (MetS) is a metabolic disorder related to obesity and insulin resistance and is the primary determinant of the development of low-intensity chronic inflammation. This continuous inflammatory response culminates in neuroimmune-endocrine dysregulation responsible for the metabolic abnormalities and morbidities observed in individuals with MetS. Events such as the accumulation of visceral adipose tissue, increased plasma concentrations of free fatty acids, tissue hypoxia, and sympathetic hyperactivity in individuals with MetS may contribute to the activation of the innate immune response, which compromises cerebral microcirculation and the neurovascular unit, leading to the onset or progression of neurodegenerative diseases.
View Article and Find Full Text PDFDiabetol Metab Syndr
January 2025
Department of Clinical Nutrition, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, Saudi Arabia.
Background: The potential therapeutic role of magnesium (Mg) in type 2 diabetes mellitus (T2DM) remains insufficiently studied despite its known involvement in critical processes like lipid metabolism and insulin sensitivity. This study examines the impact of Mg-focused nutritional education on lipid profile parameters, total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) in T2DM patients.
Methods: Thirty participants with T2DM were recruited for this within-subject experimental study.
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