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Design, evaluation, and in vitro-in vivo correlation of self-nanoemulsifying drug delivery systems to improve the oral absorption of exenatide.
J Control Release
January 2025
Department of Pharmacy, University of Copenhagen, Universitetsparken 2, Copenhagen 2100, Denmark; Bioneer A/S, Kogle Allé 2, Hørsholm 2970, Denmark. Electronic address:
The ability to predict the absorption of exenatide (Ex), a GLP-1 analogue, after oral dosing to rats in self-nanoemulsifying drug delivery systems (SNEDDS), using in vitro methods, was assessed. Ex was complexed with soybean phosphatidylcholine (SPC) prior to loading into SNEDDS. A design of experiments (DoE) approach was employed to develop SNEDDS incorporating medium-chain triglycerides (MCT), medium-chain mono- and diglycerides (MGDG), Kolliphor® RH40, and monoacyl phosphatidylcholine.
View Article and Find Full Text PDFCombined exercise-induced modulation of Notch pathway and muscle quality in senescence-accelerated mice.
Pflugers Arch
January 2025
School of Physical Education and Sport of Ribeirão Preto, University of São Paulo (USP), Avenida Bandeirantes, 3900, Monte Alegre, Ribeirão Preto, São Paulo, 14040-907, Brazil.
The Notch signaling pathway is crucial for skeletal muscle development, regeneration, inflammation, and aging. This study investigated the association between interleukin-10 (IL-10) and the Notch pathway in C2C12 cells, as well as explored the effects of combined endurance and resistance exercise on the Notch and autophagy pathways in the skeletal muscle of senescence-accelerated mouse-resistant 1 Sedentary (SAMR1 CT), SAMR1 exercised (SAMR1 EX), senescence-accelerated prone mouse 8 Sedentary (SAMP8 CT), and SAMP8 exercised (SAMP8 EX). C2C12 myoblasts were transfected with siIL-10.
View Article and Find Full Text PDFReply: evaluating Microsoft Bing with ChatGPT-4 for the assessment of abdominal computed tomography and magnetic resonance images.
Diagn Interv Radiol
January 2025
Ege University Faculty of Medicine, Department of Radiology, İzmir, Türkiye.
Evaluating ChatGPT and Google Gemini Performance and Implications in Turkish Dental Education.
Cureus
January 2025
Pedodontics, Istanbul Turkuaz Dental Clinic, Istanbul, TUR.
Artificial intelligence (AI) has emerged as a transformative tool in education, particularly in specialized fields such as dentistry. This study evaluated the performance of four advanced AI models - ChatGPT-4o (San Francisco, CA: OpenAI), ChatGPT-o1, Gemini 1.5 Pro (Mountain View, CA: Google LLC), and Gemini 2.
View Article and Find Full Text PDFThe role of artificial intelligence in gynecologic and obstetric emergencies.
Eur J Obstet Gynecol Reprod Biol
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Department of Gynecology and Obstetrics, University Clinic Erlangen, Comprehensive Cancer Center Erlangen-EMN (CCC ER-EMN), Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany. Electronic address:
Objective: To investigate the potential of artificial intelligence (AI) in emergency medicine, focusing on its utility in triaging and managing acute gynecologic and obstetric emergencies.
Methods And Materials: This feasibility study assessed Chat-GPT's performance in triaging and recommending management interventions for gynecologic and obstetric emergencies, using ten fictive cases. Five common conditions were modeled for each specialty.
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