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Genetic associations of plasma metabolites with immune cells in hyperthyroidism revealed by Mendelian randomization and GWAS-sc-eQTLs xQTLbiolinks analysis.
Sci Rep
January 2025
The Department of General Surgery, Zhongshan City People's Hospital, Zhongshan, 528400, Guangdong Province, China.
Mendelian randomization (MR) was employed to investigate the causal relationships between immune cell phenotypes, hyperthyroidism (HD), and potential metabolic mediators. In this study, we acquired 731 immune cell phenotypes from genome-wide association studies (GWAS) (n = 18,622), HD data from the research by Handan Melike Dönertaş et al. (3,731 cases, 480,867 controls), and aggregated statistics of 1,400 blood metabolites from UK Biobank (n = 115,078).
View Article and Find Full Text PDFBoosting skin cancer diagnosis accuracy with ensemble approach.
Sci Rep
January 2025
School of Information and Electronic Engineering and Zhejiang Key Laboratory of Biomedical Intelligent Computing Technology, Zhejiang University of Science and Technology, No. 318, Hangzhou, Zhejiang, China.
Skin cancer is common and deadly, hence a correct diagnosis at an early age is essential. Effective therapy depends on precise classification of the several skin cancer forms, each with special traits. Because dermoscopy and other sophisticated imaging methods produce detailed lesion images, early detection has been enhanced.
View Article and Find Full Text PDFPET Imaging of Sphingosine-1-Phosphate Receptor 1 with [F]TZ4877 in Nonhuman Primates.
Mol Imaging Biol
January 2025
Yale PET Center, Yale School of Medicine, New Haven, USA.
Purpose: The sphingosine-1-phosphate receptor-1 (S1PR) is involved in regulating responses to neuroimmune stimuli. There is a need for S1PR-specific radioligands with clinically suitable brain pharmcokinetic properties to complement existing radiotracers. This work evaluated a promising S1PR radiotracer, [F]TZ4877, in nonhuman primates.
View Article and Find Full Text PDFDeterminants of knowledge of preconception care among healthcare providers in Ethiopia: a systematic review and meta-analysis.
BMJ Open
January 2025
Department of Nursing, College of Health science, Ambo University, Ambo, Ethiopia.
Objective: To assess the determinants of knowledge of preconception care (PCC) among healthcare providers in Ethiopia.
Design: Systematic review and meta-analysis.
Data Source: Comprehensive literature searches were conducted in PubMed, Scopus and Health Internetwork Access to Research Initiative (HINARI) published until 20 March 2024.
Asparagopsis taxiformis supplementation to mitigate enteric methane emissions in dairy cows - effects on performance and metabolism.
J Dairy Sci
January 2025
Department of Applied Animal Science & Welfare, Swedish University of Agricultural Sciences (SLU), Box 7024, 753 23 Uppsala, Sweden.
Methane emissions from ruminant digestion contribute significantly to global anthropogenic greenhouse gas emissions. Members of the phylum Rhodophyta (red algae), particularly Asparagopsis sp., have shown promising results in reducing methane emissions in ruminants, due to their high content of halogenated methane analog compounds.
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