AI Article Synopsis
- The study investigated the link between various inflammation-related indexes (SII, NLR, PPN, PLR) and vertebral fractures in older Americans aged 60 and above.
- Using data from the 2013-2014 NHANES database, the researchers applied statistical models to analyze the association and predictive value of these indexes on vertebral fractures.
- The findings revealed that only the neutrophil-to-lymphocyte ratio (NLR) was significantly associated with vertebral fractures, highlighting its potential use as a predictive marker for fracture risk in older adults.
Article Abstract
Objective: This study was to examine the association between inflammation-related indexes SII (systemic immune-inflammation index), NLR (neutrophil-to-lymphocyte ratio), PPN (product of platelet count and neutrophil count), and PLR (platelet-to-lymphocyte ratio), and the occurrence of vertebral fractures in older Americans.
Methods: Patients ⩾60 years of age from the 2013-2014 NHANES database were selected for this study. Restricted cubic spline models and weighted logistic regression models were used to assess the association between inflammation-related indexes and the occurrence of vertebral fractures in older Americans. The predictive value of the inflammation-related indexes on the occurrence of vertebral fractures was assessed using receiver operating characteristic curves (ROC). To examine the robustness of the main findings, a sensitivity analysis was conducted.
Results: A total of 1281 patients were included in the analysis, of whole 120 suffered vertebral fractures. Fully adjusted logistic regression showed a significant linear relationship between NLR and the occurrence of vertebral fracture in older Americans (p < .05), but no relationship was found between SII, PLR, and the occurrence of vertebral fracture in older Americans. Meanwhile, NLR was slightly better than other indicators in predicting vertebral fracture.
Conclusions: This study found that NLR, as a novel inflammatory marker, can predict the risk of vertebral fracture in older Americans, which is of clinical significance for the prevention and treatment of vertebral fracture in older adults.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11542303 | PMC |
| http://dx.doi.org/10.1002/iid3.70047 | DOI Listing |
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