We report a new streamlined approach for the difluoromethylation of ubiquitous phenols using inexpensive bromo(difluoro)acetic acid, yielding a wide array of structurally diverse OCFH-based building blocks in a single step. This method displays broad functional group compatibility and is amenable for effective late-stage diversification and lignin-derived monomers.
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| http://dx.doi.org/10.1039/d4cc04782f | DOI Listing |
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