AI Article Synopsis
- 2'--ribose methylation (2'--Me) is a widespread RNA modification found in ribosomal RNAs across different organisms, from bacteria to humans, that aids in RNA stability and conformation.
- The frequency of 2'--Me varies significantly among species, with bacteria having about 3-4 modification sites, while more complex organisms may have tens of sites.
- The process of adding 2'--Me involves site-specific RNA methyltransferases (RMTases), which can either be unique for certain sites or shared among various RNA guides, and the review focuses on recent findings related to rRNA 2'--Me in plants and its comparative analysis with simpler organisms.
Article Abstract
2'--ribose methylation (2'--Me) is one of the most common RNA modifications detected in ribosomal RNAs (rRNA) from bacteria to eukaryotic cells. 2'--Me favours a specific RNA conformation and protects RNA from hydrolysis. Moreover, rRNA 2'--Me might stabilize its interactions with messenger RNA (mRNA), transfer RNA (tRNA) or proteins. The extent of rRNA 2'--Me fluctuates between species from 3-4 sites in bacteria to tens of sites in archaea, yeast, algae, plants and human. Depending on the organism as well as the rRNA targeting site and position, the 2'--Me reaction can be carried out by several site-specific RNA methyltransferases (RMTase) or by a single RMTase associated to specific RNA guides. Here, we review current progresses in rRNA 2'--Me (sites/Nm and RMTases) in plants and compare the results with molecular clues from unicellular (bacteria, archaea, algae and yeast) as well as multicellular (human and plants) organisms.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11542601 | PMC |
| http://dx.doi.org/10.1080/15476286.2024.2417152 | DOI Listing |
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