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Optimising Anti-D Use: Revisiting Guidelines for First Trimester Abortions.
BJOG
November 2024
Centre for Reproductive Health, University of Edinburgh, Edinburgh, UK.
Outcome predictors for maternal red blood cell alloimmunisation with anti-K and anti-D managed with intrauterine blood transfusion.
Br J Haematol
February 2022
Fetal Medicine Unit, Ontario Fetal Center, Mount Sinai Hospital, Toronto, Ontario, Canada.
Red blood cell (RBC) alloimmunisation with anti-D and anti-K comprise the majority of cases of fetal haemolytic disease requiring intrauterine red cell transfusion (IUT). Few studies have investigated which haematological parameters can predict adverse fetal or neonatal outcomes. The aim of the present study was to identify predictors of adverse outcome, including preterm birth, intrauterine fetal demise (IUFD), neonatal death (NND) and/or neonatal transfusion.
View Article and Find Full Text PDFFetal RHD detection from circulating cell-free fetal DNA in maternal plasma: validation of a diagnostic kit using automatic extraction and frozen DNA.
Transfus Med
December 2019
Department of Transfusion Medicine, ASUI-Udine, Udine, Italy.
Objective: This study aimed to validate non-invasive RHD genotyping of cell-free fetal DNA (cff-DNA) using different DNA extraction methods and of fresh and frozen extracted cff-DNA.
Background: Non-invasive RHD genotyping of cff-DNA predicts fetal RhD phenotype, allowing for the rational implementation of antenatal immunoprophylaxis and representing a big step forward in the management of RhD-immunised women. Validation of a diagnostic method is mandatory before its clinical application.
An investigation of secondary anti-D immunisation among phenotypically RhD-negative individuals in the Chinese population.
Blood Transfus
April 2014
Department of Blood Transfusion, the Shaoxing Hospital of China Medical University, Shaoxing, Zhejiang, People's Republic of China.
Background: Despite the introduction of anti-D prophylaxis into clinical practice, RhD alloimmunisation remains a problem, particularly in the context of transfusions and pregnancy-induced alloimmunisation. The incidence of RhD alloimmunisation among phenotypically RhD-negative individuals is unknown in most countries. We investigated RhD alloimmmunisation in RhD-negative pregnant women and transfusion recipients in south-east China in order to optimise the prevention of this phenomenon.
View Article and Find Full Text PDFMonoclonal blood group antibodies.
Beitr Infusionsther
February 1990
Regional Transfusion and Immuno-Haematology Centre, Cambridge, England.
The large volume requirements for high quality AB0 and RhD typing reagents can now be supplied by selected monoclonal antibodies. Superior anti-A and anti-B monoclonal reagents are each prepared from blends of two antibodies to optimise the intensity of agglutination for slide tests and the potency for detection of the weaker sub-groups, including Ax and Bw by tube techniques. Excellent anti-A,B reagents must also be made by blends of at least two antibodies to optimise both A and B reactions, but the need for their continued use is now debatable.
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