Cannabinoid receptor activation has been proposed to trigger glutamate release from astrocytes located in cortical layer 2/3. Here, we measure the basal concentration of extracellular glutamate in layer 2/3 of mouse somatosensory cortex and find it to be 20-30 nM. We further examine the effect of cannabinoid receptor signaling on extracellular glutamate, and find no evidence for increased extracellular glutamate upon cannabinoid receptor agonist application.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11541540 | PMC |
| http://dx.doi.org/10.1038/s41598-024-75962-5 | DOI Listing |
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