AI Article Synopsis

  • This study focuses on minimal change disease (MCD), a common type of nephrotic syndrome, aiming to create a predictive model for relapse probability in affected patients.
  • A total of 152 patients with confirmed MCD were assessed using Cox regression analysis to identify key risk factors for relapse and to develop a nomogram for predictions.
  • Key independent risk factors for relapse included high serum IgE levels, age ≤ 30, low eGFR, high cholesterol levels, and time to remission, with the nomogram showing strong predictive accuracy for relapse over 1-3 years.

Article Abstract

Background: Minimal change disease (MCD) is a common pathological type of nephrotic syndrome. Relapses of MCD present a significant challenge for patients. This study aims to develop a predictive model for evaluating the probability of relapse in patients with MCD.

Methods: This study enrolled 152 patients with biopsy-confirmed MCD, all of whom received exclusive glucocorticoid treatment at the First Affiliated Hospital of Zhejiang University in Hangzhou, China, between October 2012 and April 2021. The Cox regression analysis was utilized to identify the risk factors associated with the relapse in MCD, and a nomogram was constructed to predict the probability of relapse.

Results: The results demonstrated that serum immunoglobulin E (IgE) levels > 936 IU/mL, age ≤ 30 years old, estimated glomerular filtration rate (eGFR) < 90 mL/(min × 1.73 m), serum total cholesterol (TCh) levels > 12.3 mmol/L, and time to remission were independent risk factors associated with relapses in patients with MCD. A nomogram was established and achieved a concordance index of 0.726 (95% CI = 0.659-0.793). The receiver operating characteristic curves demonstrated areas under the curve of 0.771, 0.853, and 0.811 for the prediction of relapse at 1-, 2-, and 3-year intervals after achieving remission in MCD patients respectively. These findings along with the calibration curves indicated the good discrimination and calibration performance of the nomogram in this cohort.

Unlabelled: The established nomogram provides a valuable tool for the identification of patients with MCD who are at risk of relapse, which may facilitate prompt treatment for these patients.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11544732PMC
http://dx.doi.org/10.1080/0886022X.2024.2423007DOI Listing

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