Notch signaling is a highly conserved pathway activated by dynamic cellular interactions that initiates a molecular cascade that ultimately drives changes in gene expression. The Notch transcriptional complex (NTC) regulates genes that influence development and homeostasis. In this issue of , Rogers and colleagues (doi:10.1101/gad.352108.124) leverage a rapid Notch activation system combined with molecular genomic profiling to reveal that the NTC regulates the release of paused RNA polymerase to activate direct target genes. They also highlight the role of the SWI/SNF chromatin remodeling complex in establishing and maintaining chromatin accessibility to potentiate the activation of NTC target genes.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11610930 | PMC |
| http://dx.doi.org/10.1101/gad.352340.124 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Classifying the molecular functions of transcription factors beyond activation and repression.
Genes Dev
November 2024
Center for Cell Analysis and Modeling, University of Connecticut, Farmington, Connecticut 06030, USA
Notch signaling is a highly conserved pathway activated by dynamic cellular interactions that initiates a molecular cascade that ultimately drives changes in gene expression. The Notch transcriptional complex (NTC) regulates genes that influence development and homeostasis. In this issue of , Rogers and colleagues (doi:10.
View Article and Find Full Text PDFGeneralization and enhancement of the effects of an active placebo nasal spray on sadness.
J Affect Disord
January 2025
Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona, Italy; Department of Psychology, Università Cattolica del Sacro Cuoro, Milan, Italy.
Article Synopsis
- The study examines the placebo effect, specifically how an active placebo that mimics drug side effects can influence feelings of sadness, especially when presented in a positive light.
- Ninety-six participants were divided into three groups to test the effectiveness of placebos with positive framing versus standard information and a control group, using self-reported measures of sadness.
- Results indicated that both placebo groups reported less sadness than the control, with the positive framing group maintaining lower sadness levels after six hours, but positive framing did not improve tolerability of side effects.*
Early placement of a non-invasive, pressure-regulated, fascial reapproximation device improves reduction of the fascial gap in open abdomens: a retrospective cohort study.
Trauma Surg Acute Care Open
October 2024
Department of Surgery, Division of General Surgery St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada.
Background: Since current fascial traction methods involve invasive procedures, they are generally employed late in the management of the open abdomen (OA). This study aimed to evaluate early versus late placement of a non-invasive, pressure-regulated device for fascial reapproximation and gap reduction in OA patients.
Methods: The study included all patients who had the abdominal fascia intentionally left open after damage control operation for trauma and emergency general surgery and were managed with the device in an academic hospital between January 1, 2020, and December 31, 2023.
Engineering of Bioresorbable Polymers for Tissue Engineering and Drug Delivery Applications.
Adv Healthc Mater
December 2024
Tshwane University of Technology, Department of Chemical, Metallurgical and Materials Engineering, Polymer Division & Institute for Nano Engineering Research (INER), Pretoria West Campus, Pretoria, South Africa.
Article Synopsis
- - The text reviews recent advancements in resorbable polymeric biomaterials, focusing on their forms, how they break down in the body, and their uses in various medical fields like tissue engineering and drug delivery.
- - It discusses engineering methods for creating polymeric scaffolds tailored for applications in surgery, cardiology, dental work, and more, while also highlighting the use of medical imaging techniques to evaluate these materials.
- - Finally, the text addresses the legal regulations and challenges faced in turning research into practical, marketable polymer-based medical solutions.
PRL1 interacts with and stabilizes RPA2A to regulate carbon deprivation-induced senescence in Arabidopsis.
New Phytol
November 2024
State Key Laboratory of Crop Stress Resistance and High-Efficiency Production and College of Life Sciences, Northwest A&F University, Yangling, Shaanxi, 712100, China.
Leaf senescence is a developmental program regulated by both endogenous and environmental cues. Abiotic stresses such as nutrient deprivation can induce premature leaf senescence, which profoundly impacts plant growth and crop yield. However, the molecular mechanisms underlying stress-induced senescence are not fully understood.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!