AI Article Synopsis
- This study examined how reducing cocaine use affects the immune system in individuals with Cocaine Use Disorder.
- Participants were divided into three groups based on the value of financial rewards they received for abstaining from cocaine, with the highest rewards leading to the most significant reductions in use.
- The findings indicated that the group receiving high rewards not only reduced cocaine use significantly but also showed changes in immune markers, indicating an activated immune response that could reflect improved immune health.
Article Abstract
This study determined the effects of reduced cocaine use on immune function. Treatment seeking participants with Cocaine Use Disorder enrolled in a 12-week contingency management trial to reduce cocaine use. Participants were randomly assigned 1:1:1 to High Value Reinforcers (i.e., $55/negative urine sample) for cocaine abstinence (n = 41), Low Value Reinforcers (i.e., $13/negative urine sample) for cocaine abstinence (n = 33) or Non-Contingent Control (n = 33). Immune measures were collected at 6-week intervals. The High Value group had greatest use reductions, increased erythema and IL-6 and decreased IL-10 and CCL5, suggesting an activated immune response. Cocaine use reduction may promote changes in immune health.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11620913 | PMC |
| http://dx.doi.org/10.1016/j.jneuroim.2024.578470 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!