AI Article Synopsis
- - The study highlights LINC02466 as a long non-coding RNA linked to negative outcomes in primary liver cancer (HCC) and its potential role as a therapeutic target for treatment.
- - Techniques like RT-qPCR and Western Blot were used to measure LINC02466 levels in liver tissues, while CCK8 assays and colony formation experiments showed its impact on cancer cell growth and the cell cycle.
- - Findings indicate that suppressing LINC02466 reduces cancer cell characteristics, while its overexpression boosts tumor growth, suggesting its influence on liver cancer progression through the mTOR signaling pathway.
Article Abstract
Objective: Long non-coding RNAs (lncRNAs) LINC02466 is an lncRNA newly linked to the adverse outcomes in primary liver cancer patients, and its crucial involvement in the disease's escalation. Decoding the specific role of LINC02466 in HCC progression is of great significance to provide a potential therapeutic target for HCC.
Methods: RT-qPCR and Western Blot techniques was used to analyze the expression levels of LINC02466 in both malignant and surrounding healthy liver tissues. CCK8 assays and colony formation experiments indicates the LINC02466's effect on the proliferation rates of liver cancer cells. Flow cytometry was pivotal in revealing its significant influence on the cell cycle of these cells. Kaplan-Meier survival analysis with log-rank tests were employed.
Results: The suppression of LINC02466 markedly reduces the stemness attributes of liver cancer cells, indicating a potential therapeutic target. LINC02466 overexpression significantly increased tumor growth rates and final volumes. Further research indicated that LINC02466 significantly influences liver cancer progression through regulating the mTOR signaling pathway.
Conclusion: LINC02466 regulating cell proliferation, the cell cycle, and stemness characteristics via the mTOR pathway, suggesting LINC02466 as a potential therapeutic target for primary liver cancer.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11541976 | PMC |
| http://dx.doi.org/10.1007/s12672-024-00999-x | DOI Listing |
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