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Development of the AIIMS Bhopal Pre-sternal Keloid Scale (ABPSKS): A Tool for Assessing Severity and Comparing Treatment Outcomes.
Cureus
December 2024
Obstetrics and Gynaecology, All India Institute of Medical Sciences Bibinagar, Hyderabad, IND.
Pre-sternal keloids are a distinct clinicopathological entity differing in many ways from keloids occurring elsewhere, as there are differences in pathogenesis, clinical presentation, and management. We have reviewed commonly used assessment scales like the Vancouver Scar Scale, the Patient and Observer Scar Assessment Scale, and the Detroit Keloid Scale and identified some shortcomings in applying them in assessing pre-sternal keloids. Therefore, we developed the AIIMS Bhopal pre-sternal keloid scale (ABPSKS), a pre-sternal keloid-specific tool to enable the assessment of the severity of the disease, the efficacy of treatment, and the comparison of outcomes of different treatment modalities.
View Article and Find Full Text PDFIdentification and validation of five ferroptosis-related molecular signatures in keloids based on multiple transcriptome data analysis.
Front Mol Biosci
January 2025
Department of Plastic Surgery, Second Hospital and Clinical Medical School, Lanzhou University, Lanzhou, China.
Introduction: Keloids are a common skin disorder characterized by excessive fibrous tissue proliferation, which can significantly impact patients' health. Ferroptosis, a form of regulated cell death, plays a crucial role in the development of fibrosis; however, its role in the mechanisms of keloid formation remains poorly understood.
Methods: This study aimed to identify key genes associated with ferroptosis in keloid formation.
is overexpressed in keloid keratinocytes and its inhibition alters profibrotic gene expression.
Burns Trauma
January 2025
Department of Surgery, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH, 45267, USA.
Background: Keloids are disfiguring, fibrotic scar-like lesions that are challenging to treat and commonly recur after therapy. A deeper understanding of the mechanisms driving keloid formation is necessary for the development of more effective therapies. Reduced vitamin D receptor (VDR) expression has been observed in keloids, implicating vitamin D signaling in keloid pathology.
View Article and Find Full Text PDFSuccessful treatment of a keloid on the upper lip by trepanation and radiotherapy: a case report.
J Dermatolog Treat
December 2025
Department of Dermatology and Venereology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Keloid tissue represents an abnormal proliferation of fibroblasts, typically resulting from skin injury. These lesions can lead to significant physiological dysfunction and aesthetic concerns, particularly when located on the face. Traditional treatments, such as intralesional injections, laser therapy, and surgical excision, have shown limited efficacy and are associated with high recurrence rates.
View Article and Find Full Text PDFLeveraging Microneedles for Raised Scar Management.
Polymers (Basel)
January 2025
Department of Mechanical, Robotics and Energy Engineering, Dongguk University, Jung-gu, Seoul 04620, Republic of Korea.
Disruption of the molecular pathways during physiological wound healing can lead to raised scar formation, characterized by rigid, thick scar tissue with associated symptoms of pain and pruritus. A key mechanical factor in raised scar development is excessive tension at the wound site. Recently, microneedles (MNs) have emerged as promising tools for scar management as they engage with scar tissue and provide them with mechanical off-loading from both internal and external sources.
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