Long noncoding RNAs (lncRNAs) have emerged as critical regulators in the development of colorectal cancer (CRC). Previous studies indicate that lncRNA is highly expressed in CRC, but its role in modulating CRC via the signaling pathway remains unclear. In this study, we found that promotes the growth of the CRC cell line (HCT116) and drives epithelial-mesenchymal transition (EMT) through the signaling pathway. Our data showed that expression is significantly upregulated in HCT116, and elevated levels of are associated with poor prognosis in patients with CRC. In addition, the knockdown of markedly inhibited the proliferation of HCT116 by inducing cell cycle arrest. Knockdown of depletion also led to apoptosis in CRC cells by suppressing the signaling pathway and EMT, thereby reducing their viability, proliferation, migration, and invasion. In summary, this study confirmed that regulates the growth of junction HCT116 through signaling pathway and inhibiting EMT, providing new insights for the potential therapeutic strategies against CRC.
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| http://dx.doi.org/10.1089/dna.2024.0184 | DOI Listing |
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