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Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are severe mucocutaneous reactions, often triggered by medications, characterized by blistering and epithelial sloughing. We report the case of a 66-year-old male who presented with a 2-day history of fluid-filled lesions on his body. On examination, erosions were observed on the posterior and anterior trunk, as well as on both upper and lower limbs.
View Article and Find Full Text PDFLiterature review and case report of septic arthritis and purpura fulminans leading to a child limb amputation as chickenpox complications.
Ann Med Surg (Lond)
September 2024
Al Quds University School of Medicine, Faculty of Medicine, Al Quds University, Palestine.
Introduction And Significance: Chickenpox, induced by the varicella-zoster virus (VZV), generally presents with an itchy rash and fluid-filled blisters. While complications such as pneumonia and sepsis are well-documented, occurrences of septic arthritis and purpura fulminans are exceedingly rare. Septic arthritis following varicella infection is infrequently reported and often attributed to .
View Article and Find Full Text PDFBurden of Disease of Bullous Pemphigoid: A Targeted Literature Review.
Dermatology
December 2024
Evidera, London, UK.
Article Synopsis
- Bullous pemphigoid (BP) is a rare autoimmune skin disease primarily affecting older adults, leading to blistering lesions and a high mortality rate of 27-72%.
- A review analyzed 42 studies highlighting the clinical, humanistic, and economic impacts of BP, revealing that many patients experience severe symptoms, comorbidities, and significant mental health issues like depression and anxiety.
- The study underscored BP's considerable burden on patients, indicating longer hospital stays and higher healthcare costs, which are important for healthcare providers to consider in treatment planning.
Functional characterization and structural prediction of hypothetical proteins in monkeypox virus and identification of potential inhibitors.
Mol Divers
July 2024
Department of Agriculture, Sher-e-Bangla Agricultural University, Dhaka, Bangladesh.
The excessive activation of the monkeypox virus (MPXV-Congo_8-156) is linked to various skin and respiratory disorders such as rashes, fluid-filled blisters, swollen lymph nodes and encephalitis (inflammation of the brain), highlighting MPXV-Congo_8-156 as a promising target for drug intervention. Despite the effectiveness of Cidofovir, in inhibiting MPXV activity, its limited ability to penetrate the skin and its strong side effects restrict its application. To address this challenge, we screened 500 compounds capable of penetrating the skin and gastrointestinal tract to identify potent MPXV inhibitors.
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