AI Article Synopsis
- Gastroesophageal reflux disease (GERD) is a chronic condition divided into two types: erosive reflux disease (ERD) and non-erosive reflux disease (NERD), primarily influenced by acid secretion and managed with various acid-suppressant medications.
- Since the 1970s, treatments have evolved from histamine-H-receptor antagonists to proton pump inhibitors (PPIs), and recently, potassium-competitive acid blockers (p-CABs) like Vonoprazan have emerged, offering improved efficacy and safety.
- Vonoprazan has demonstrated effectiveness in managing ERD and related symptoms, showing potential advantages over older PPIs, with ongoing research expected to explore its long-term benefits in treating other acid-related
Article Abstract
Introduction: Gastroesophageal reflux disease (GERD) is a common debilitating chronic disease presenting in two main forms based on esophageal mucosal appearance, the erosive reflux disease (ERD) and the non-erosive reflux disease (NERD). Acid secretion is a key factor in the disease pathogenesis and management. Potent acid-suppressant drugs have been manufactured since the mid of 1970s, initially with histamine-H-receptors antagonists, and later, inhibitors of the proton pump (H-K-ATPase).More recently, potassium-competitive acid blockers (p-CABs), particularlyVonoprazan, have been introduced. Vonoprazan has shown high efficacy and safety profiles and exhibits several advantages that allow to overcome shortcomings of proton pump inhibitors (PPIs).
Areas Covered: In this review, we provide an updated summary of Vonoprazan pharmacodynamics and its role in clinical practice for the management of erosive esophagitis and GERD-related heartburn. Moreover, we discuss characteristics of Vonoprazan that allow to bypass some limitations of the older PPIs.
Expert Opinion: Long-term safety and efficacy of Vonoprazan have already been demonstrated for the induction and maintenance of ERD, preventing nocturnal acid breakthrough, reducing reflux symptoms in non-responder to standard therapy. Ongoing and future studies are expected to further elucidate its long-term benefits and potential applications in other acid-related disorders.
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| http://dx.doi.org/10.1080/14656566.2024.2427335 | DOI Listing |
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