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Protein -palmitoylation regulates the virulence of plant pathogenic fungi.
mBio
December 2024
Ministry of Agriculture Key Laboratory of Molecular Biology of Crop Pathogens and Insect Pests, Institute of Biotechnology, Zhejiang University, Hangzhou, China.
Protein -palmitoylation, a universal posttranslational modification catalyzed by a specific group of palmitoyltransferases, plays crucial roles in diverse biological processes across organisms by modulating protein functions. However, its roles in the virulence of plant pathogenic fungi remain underexplored. In a recent study, Y.
View Article and Find Full Text PDFDeoxygenative Reduction of 1°, 2° and 3° Amides via Generated Tungsten Cluster Acting as H-Bonding Donor.
Org Lett
December 2024
School of Environmental and Chemical Engineering, Jiangsu University of Science and Technology, Zhenjiang 212003, Jiangsu, P. R. China.
A protocol of amide-to-amine transformation that is convenient, mild, and easy to perform is a long-sought goal from the viewpoint of catalysis. Herein, we have utilized easily accessible W(CO)(NCMe) as a precatalyst for the deoxygenative reduction of 1°, 2° and 3° amides under mild conditions. Mechanism studies unraveled that the generated is potentially a vital species in activating C═O of amides by providing the H-bonding network during the catalytic cycle.
View Article and Find Full Text PDFMyogenic Classical Endocannabinoids, Their Targets and Activity.
Biochemistry (Mosc)
October 2024
Faculty of Biology, Lomonosov Moscow State University, Moscow, 119234, Russia.
This review focuses on the recently discovered specific action of two classical endocannabinoids (ECs), 2-arachidonoylglycerol (2-AG) and arachidonoyl ethanolamide (AEA), in the case of their synthesis and degradation in skeletal muscles; in other words, this review is dedicated to properties and action of the myoendocannabinoid (myoEC) pool. Influence of this pool is considered at three different levels: at the level of skeletal muscles, motor synapses, and also at the level of the whole organism, including central nervous system. Special attention is paid to the still significantly underestimated and intriguing ability of ECs to have positive effect on energy exchange and contractile activity of muscle fibers, as well as on transmitter secretion in motor synapses.
View Article and Find Full Text PDFViewpoint Catalyzing Climate Solutions through Energy and Carbon Education.
Environ Sci Technol
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Department of Energy and Mineral Engineering, The Pennsylvania State University, University Park, Pennsylvania 16802, United States.
The need to identify anatomy-related competencies in medical education.
Anat Sci Educ
December 2024
Department of Anatomy, School of Medical Sciences, Health Campus, Universiti Sains Malaysia, Kubang Kerian, Malaysia.
A profound grasp of anatomy is indispensable for shaping competent and safe medical practitioners. This knowledge acquisition is pivotal in the early stages of medical education and remains crucial throughout clinical training. However, the evolving landscape of medical education has ushered in changes to the anatomy curriculum, marked by a reduction in contact hours and a streamlined content structure to accommodate novel subjects and teaching methodologies.
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