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NeuroCarto: A Toolkit for Building Custom Read-out Channel Maps for High Electrode-count Neural Probes.
Neuroinformatics
January 2025
Neuro Electronics Res. Flanders (NERF), Heverlee, 3001, Belgium.
Neuropixels probes contain thousands of electrodes across one or more shanks and are sufficiently small to allow chronic recording of neural activity in freely behaving small animals. However, the joint increase in the number of electrodes and miniaturization of the probe package has led to a compromise in which groups of electrodes share a single read-out channel and only a fraction of the electrodes can be read out at any given time. Experimenters then face the challenge of selecting a subset of electrodes (i.
View Article and Find Full Text PDFDeep-Learning Model for Mortality Prediction of ICU Patients with Paralytic Ileus.
Bioengineering (Basel)
November 2024
Department of Mechanical and Industrial Engineering, University of Illinois Chicago, 942 W Taylor St., Chicago, IL 60607, USA.
Paralytic Ileus (PI) patients in the Intensive Care Unit (ICU) face a significant risk of death. Current predictive models for PI are often complex and rely on many variables, resulting in unreliable outcomes for such a serious health condition. Predicting mortality in ICU patients with PI is particularly challenging due to the vast amount of data and numerous features involved.
View Article and Find Full Text PDFRole of Microbiota-Derived Hydrogen Sulfide (HS) in Modulating the Gut-Brain Axis: Implications for Alzheimer's and Parkinson's Disease Pathogenesis.
Biomedicines
November 2024
Department of Biomedical Sciences, Faculty of Medical Bioengineering, University of Medicine and Pharmacy "Grigore T. Popa", 700454 Iasi, Romania.
Microbiota-derived hydrogen sulfide (HS) plays a crucial role in modulating the gut-brain axis, with significant implications for neurodegenerative diseases such as Alzheimer's and Parkinson's. HS is produced by sulfate-reducing bacteria in the gut and acts as a critical signaling molecule influencing brain health via various pathways, including regulating inflammation, oxidative stress, and immune responses. HS maintains gut barrier integrity at physiological levels and prevents systemic inflammation, which could impact neuroinflammation.
View Article and Find Full Text PDFDiverse retinal ganglion cells (RGCs) transmit distinct visual features from the eye to the brain. Recent studies have categorized RGCs into 45 types in mice based on transcriptomic profiles, showing strong alignment with morphological and electrophysiological properties. However, little is known about how these types are spatially arranged on the two-dimensional retinal surface-an organization that influences visual encoding-and how their local microenvironments impact development and neurodegenerative responses.
View Article and Find Full Text PDFFace pareidolia minimally engages macaque face selective neurons.
Prog Neurobiol
January 2025
Section on Cognitive Neurophysiology and Imaging, National Institute of Mental Health; Bethesda, MD, USA; Neurophysiology Imaging Facility, National Institute of Mental Health, National Institute of Neurological Disorders and Stroke, National Eye Institute; Bethesda, MD, USA. Electronic address:
The macaque cerebral cortex contains concentrations of neurons that prefer faces over inanimate objects. Although these so-called face patches are thought to be specialized for the analysis of facial signals, their exact tuning properties remain unclear. For example, what happens when an object by chance resembles a face? Everyday objects can sometimes, through the accidental positioning of their internal components, appear as faces.
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