AI Article Synopsis
- The year 2024 marks the release of new clinical practice and management guidelines for chronic hepatitis B virus (HBV) infection, led by the World Health Organization (WHO) in March.
- Key international liver disease societies, like the AASLD and EASL, are also updating their HBV guidelines but have not yet published them.
- The chapter discusses recent developments, particularly focusing on the stringent Chinese guidelines from 2022 that recommend starting antiviral treatment at higher HBV DNA levels, examining the pros and cons of lowering treatment thresholds to prevent complications like hepatocellular carcinoma (HCC).
Article Abstract
The year 2024 is the year of new clinical practice and management guidelines for chronic hepatitis B virus (HBV) infection. World Health Organization (WHO) published the updated HBV guidelines in March 2024. In contrast, two key international societies for liver diseases, including the American Association for the Study of Liver Diseases (AASLD) and the European Association for the Study of the Liver (EASL), are currently in the process of updating their clinical practice guidelines for HBV. In 2022, China published their HBV guidelines, regarded as one of the most uncompromising ones as the threshold to start antiviral treatment is set at detectable HBV DNA above 10-20 IU/mL. In this chapter, the latest developments in the HBV guidelines with a specific focus on the Chinese & WHO guidelines are discussed. Specifically, the pros and cons of lowering treatment thresholds and the benefits of treating more people to avoid the complications of chronic hepatitis B, specifically HCC, are reviewed.
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