-rearranged renal cell carcinoma (RCC) is a rare subtype of renal tumor that typically affects the pediatric age group. Previous exposure to chemotherapy agents increases the possibility of having this subtype. Morphologically, it displays a broad spectrum of growth patterns, but it can be distinguished by the presence of melanin pigment or psammoma bodies. Osseous metaplasia is an uncommon morphological finding in this particular subtype, and it has been reported in two cases in the literature. We describe the third case of -rearranged renal cell carcinoma with osseous metaplasia in a healthy 13-year-old male, presenting with worsening abdominal pain and hematuria.
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http://dx.doi.org/10.7759/cureus.73072 | DOI Listing |
J Cancer Res Ther
December 2024
Department of Interventional Radiology, Ruijin Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China.
Objective: To evaluate the postoperative complications and prognosis of renal cell carcinoma (RCC) in a solitary kidney after irreversible electroporation (IRE).
Materials And Methods: A total of 8 patients with 9 RCCs in a solitary kidney treated with computed tomography (CT)-guided IRE from February 2017 to September 2020 were retrospectively analyzed. Follow-up included contrast-enhanced CT or magnetic resonance imaging examinations at 1 day, 1 week, 1 month, 3 months, 6 months, 12 months, and each year after IRE and the evaluation of the incidence of postoperative complications, renal function changes, local tumor recurrence, and metastasis.
Minerva Urol Nephrol
January 2025
Department of Urology, University of Verona, A.O.U.I. Verona, Italy.
World J Urol
January 2025
Medical Oncology Department, Institut de Cancérologie Strasbourg Europe, Strasbourg, France.
Purpose: Surgery remains the cornerstone of localized renal cell carcinoma (RCC) care. Pembrolizumab has recently been recommended as a standard of care for RCC patients who are at high risk of recurrence. Data regarding the efficacy of ICIs either alone or in combination with ICIs or VEGF TKIs for VTT shrinkage are scarce.
View Article and Find Full Text PDFAm J Physiol Renal Physiol
January 2025
Division of Nephrology, Department of Medicine, Duke University School of Medicine, Durham, NC, USA.
Cells
January 2025
Division of Nephrology & Hypertension, Mayo Clinic, 200 1st Street SW, Rochester, MN 55905, USA.
Metabolic syndrome (MetS) is associated with low-grade inflammation, which can be exacerbated by renal artery stenosis (RAS) and renovascular hypertension, potentially worsening outcomes through pro-inflammatory cytokines. This study investigated whether mesenchymal stem/stromal cells (MSCs) could reduce fat inflammation in pigs with MetS and RAS. Twenty-four pigs were divided into Lean (control), MetS, MetS + RAS, and MetS + RAS + MSCs.
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