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Penetration Enhancer-Free Mixed Micelles for Improving Eprinomectin Transdermal c Efficiency in Animal Parasitic Infections Therapy. | LitMetric

AI Article Synopsis

  • Eprinomectin (EPR) is being developed into mixed micelles for easier and more effective treatment of parasitic infections in animals.
  • The study involved preparing the mixed micelles and assessing their stability, size, and drug release characteristics, along with pharmacokinetic analysis in rats.
  • Findings indicated that the EPR mixed micelles are safe, have enhanced absorption, and could be a promising new method for delivering veterinary treatments.

Article Abstract

Introduction: Eprinomectin offers promise against parasitic infections. This study develops Eprinomectin (EPR) mixed micelles for transdermal delivery, aiming to enhance efficacy and convenience against endoparasites and ectoparasites. Physicochemical characterization and pharmacokinetic studies were conducted to assess its potential as an effective treatment for parasitic infections.

Methods: Blank and EPR mixed micelles were prepared using PEG-40 Hydrogenated castor oil (RH-40) and Nonyl phenol polyoxyethylene ether 40 (NP-40). Critical micelle concentrations (CMC) determined using the pyrene fluorescence probe method. Particle size, EE, DL, in vitro release, permeation, and skin irritation were evaluated. In vivo pharmacokinetic studies were conducted in male Sprague-Dawley rats.

Results: Results show that EPR mixed micelles present suitable stability, physicochemical properties, and safety. Moreover, the rapid release and high bioavailability of EPR mixed micelles have also been verified in the study. Pharmacokinetic experiments in vivo showed that an improvement in the transdermal absorption and bioavailability of EPR after encapsulation in mixed micelles formulations.

Conclusion: The results proved that the novel mixed micelles are safe and effective and are expected to become a promising veterinary nano-delivery system.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11537163PMC
http://dx.doi.org/10.2147/IJN.S476164DOI Listing

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