AI Article Synopsis

  • Epileptic seizures are dangerous neurological events that require early detection for effective treatment, leading to the development of advanced artificial intelligence methods for improved detection.
  • This study introduces a new ensemble approach, combining fast independent component analysis random forest (FIR) and prediction probability, using EEG data to enhance the early detection of seizures.
  • Experimental results show that the FIR model, particularly when combined with support vector machine (FIR + SVM), achieves a high detection accuracy of 98.4%, indicating its potential for early diagnosis and improved patient outcomes in the medical field.

Article Abstract

Objective: Epileptic seizures are neurological events that pose significant risks of physical injuries characterized by sudden, abnormal bursts of electrical activity in the brain, often leading to loss of consciousness and uncontrolled movements. Early seizure detection is essential for timely treatments and better patient outcomes. To address this critical issue, there is a need for an advanced artificial intelligence approach for the early detection of epileptic seizure disorder.

Methods: This study primarily focuses on designing a novel ensemble approach to perform early detection of epileptic seizure disease with high performance. A novel ensemble approach consisting of a fast, independent component analysis random forest (FIR) and prediction probability is proposed, which uses electroencephalography (EEG) data to investigate the efficacy of the proposed approach for early detection of epileptic seizures. The FIR model extracts independent components and class prediction probability features, creating a new feature set. The proposed model combined integrated component analysis (ICA) with predicting probability to enhance seizure recognition accuracy scores. Extensive experimental evaluations demonstrate that FIR assists machine learning models to obtain superior results compared to original features.

Results: The research gap is addressed using combined features to improve the performance of epileptic seizure detection compared to a single feature set. In particular, the ensemble model FIR with support vector machine (FIR + SVM) outperforms other methods, achieving an accuracy of 98.4% for epileptic seizure detection.

Conclusions: The proposed FIR has the potential for early diagnosis of epileptic seizures and can significantly help the medical industry with enhanced detection and timely interventions.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11536591PMC
http://dx.doi.org/10.1177/20552076241277185DOI Listing

Publication Analysis

Top Keywords

epileptic seizures
16
epileptic seizure
16
prediction probability
12
early detection
12
detection epileptic
12
combined features
8
independent components
8
eeg data
8
seizure detection
8
approach early
8

Similar Publications

Rationale: PCDH19-related epilepsy manifested various clinical features, including febrile epilepsy, with or without intellectual disability, and psych-behavioral disorders. However, there are few studies demonstrating abdominal pain as the first symptom.

Patient Concerns: A 3-year-old Chinese girl presented with clustered seizures of fever sensitivity accompanied by abdominal pain.

View Article and Find Full Text PDF

Rationale: Developmental and epileptic encephalopathy (DEE) defines a group of severe and heterogeneous neurodevelopmental disorders. The voltage-gated potassium channel subfamily 2 voltage-gated potassium channel α subunit encoded by the KCNB1 gene is essential for neuronal excitability. Previous studies have shown that KCNB1 variants can cause DEE.

View Article and Find Full Text PDF

Detecting directional couplings from time series is crucial in understanding complex dynamical systems. Various approaches based on reconstructed state-spaces have been developed for this purpose, including a cross-distance vector measure, which we introduced in our recent work. Here, we devise two new cross-vector measures that utilize ranks and time series estimates instead of distances.

View Article and Find Full Text PDF

Ganaxolone: A Review in Epileptic Seizures Associated with Cyclin-Dependent Kinase-Like 5 Deficiency Disorder.

Paediatr Drugs

January 2025

Springer Nature, Private Bag 65901, Mairangi Bay, Auckland, 0754, New Zealand.

Oral ganaxolone (ZTALMY), a synthetic analogue of the endogenous neuroactive steroid allopregnanolone, acts as a positive allosteric modulator of synaptic and extra-synaptic γ-aminobutyric acid (GABA) type A receptor function in the CNS. In the EU and the UK, it is approved for the adjunctive treatment of epileptic seizures associated with cyclin-dependent kinase-like 5 (CDKL5) deficiency disorder (CDD) in patients aged 2-17 years. In a multinational phase III study (Marigold), 17 weeks' therapy with adjunctive ganaxolone, administered orally three times daily with food, significantly reduced 28-day major motor seizure frequency from baseline versus placebo in patients aged 2-19 years with CDD-associated refractory epilepsy.

View Article and Find Full Text PDF

Computational Analysis of Missense Mutations: Insight into Protein Structure and Interaction Dynamics.

ACS Chem Neurosci

January 2025

Laboratory for Innovative Drugs (Lab4IND), Computational Drug Design Center (HITMER), Bahçeşehir University, 34734 İstanbul, Türkiye.

is implicated in a range of conditions, including autism spectrum disorder, intellectual disability, seizures, autosomal recessive nonsyndromic intellectual disability, heterotaxy, and ciliary dysfunction. In order to understand the molecular mechanisms underlying these conditions, we focused on the structural and dynamic activity consequences of mutations within this gene. In this study, whole exome sequencing identified the c.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!