AI Article Synopsis
- - Mitochondria are crucial for brain function and their dysfunction is associated with age-related cognitive decline.
- - A study using rats examined if the mitochondrial respiratory capacity changes with cognitive aging, focusing on the frontal cortex.
- - Results showed no significant differences in mitochondrial oxygen consumption or ATP synthase activity between young and aged rats, indicating that mitochondrial function may not be a key factor in cognitive impairment related to aging.
Article Abstract
Mitochondria are essential for supporting the high metabolic demands that are required for brain function. Impairments in mitochondria have been linked to age-related decline in brain functions. Here, we investigate whether the mitochondrial respiratory capacity of brain cells is changed in cognitive aging. We used a rat model of normal cognitive aging and analyzed mitochondrial oxidative phosphorylation in frozen brain samples. Mitochondrial oxygen consumption rate analysis of the frontal cortex did not show any differences between young rats and aged rats with either intact memory or impaired spatial memory. Mitochondrial ATP synthase activity and quantity also did not differ between young and aged rats. These results suggest that the total level of mitochondrial respiratory capacity is preserved in the frontal cortex of aged rats and may not explain aging-associated cognitive impairment.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11536044 | PMC |
| http://dx.doi.org/10.17912/micropub.biology.001359 | DOI Listing |
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