AI Article Synopsis
- Sjögren's disease (SjD) is an autoimmune disorder causing dry eyes and mouth, often linked to symptoms like fatigue and pain due to chronic inflammation.
- The causes of SjD are not fully understood but are thought to involve a mix of environmental, genetic, hormonal, and metabolic factors.
- Recent research indicates that cholesterol metabolism might play a significant role in both immune and non-immune processes related to SjD.
Article Abstract
Sjögren's disease (SjD) is a systemic autoimmune disorder characterized by dry eyes and mouth caused by chronic inflammation and is often accompanied by various extra-glandular manifestations, including fatigue and diffuse pain. Although the pathogenesis of the disease remains elusive, several factors (e.g. environmental, genetic and hormonal factors, abnormal metabolic status) are associated with this condition. Accumulating evidence suggests a potential role of cholesterol metabolism in immune and non-immune modulation in various diseases. In this review, we summarize the current findings on the associations between cholesterol metabolism and SjD.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11535258 | PMC |
| http://dx.doi.org/10.1016/j.jdsr.2024.06.002 | DOI Listing |
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