AI Article Synopsis
Article Abstract
Objective: This study aimed to assess the effects of multi-strain probiotics on anthropometric and biochemical measures in Saudi adults with overweight or obesity.
Design: Single-centre, double-blind, placebo-controlled, randomised clinical trial.
Setting: Occupational Health Clinics at King Saud University Medical City, Riyadh, Saudi Arabia.
Participants: Ninety-three Saudi participants with overweight or obesity were randomly assigned to receive twice-daily doses of either placebo ( 49) or 30 × 10 CFU/g of HEXBIO® containing three and three species ( 44) in a double-blind manner over a 12-week period, respectively. Both groups adhered to a hypoenergetic diet. Anthropometric measurements, glycaemic indices and lipid profiles were evaluated at baseline and post-intervention.
Results: Following the 12-week intervention, no statistically significant differences were found in all between the probiotic group and placebo group comparisons, except for fat intake, where the group*time interaction showed a significant decrease in favour of the probiotic group ( = 0·02). However, significant within-group reductions were observed in the probiotic group: body weight (-0·9 kg, = 0·02), HC (-1·5 cm, = 0·002), energy intake (-387·3 kcal/d, = 0·002), fasting glucose (-0·7, = 0·002) and LDL-cholesterol (-0·7, = 0·02).
Conclusion: Consumption of multi-strain probiotic supplementation over 12 weeks significantly decreased fat intake in Saudi adults with overweight or obesity, with the probiotic group highlighting improved anthropometric and biochemical parameters. Further research is needed to evaluate the long-term clinical significance of this dietary practice and whether it has a meaningful impact on overall health beyond the placebo effect.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11645120 | PMC |
| http://dx.doi.org/10.1017/S1368980024002003 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Preparation, characterization and activity verification of xylooligosaccharides from plantain straw.
Heliyon
December 2024
Chongqing Jiangbei District Disease Control Center, Chongqing, 400020, China.
Currently, the utilization value of plantain straw is low. To increase its value, plantain straw was utilized in this study to produce xylooligosaccharides (XOS). XOS were obtained from plantain straw through xylanase hydrolysis.
View Article and Find Full Text PDFOral administration of Bifidobacterium longum and Bifidobacterium infantis ameliorates cefcapene pivoxil-induced attenuation of anti-programmed cell death protein-1 antibody action in mice.
Biomed Pharmacother
December 2024
Department of Clinical Immuno-Oncology, Clinical Research Institute for Clinical Pharmacology and Therapeutics, Showa University, Tokyo, Japan; Division of Medical Oncology, Department of Medicine, Showa University Graduate School of Medicine, Tokyo, Japan. Electronic address:
Gut bacteria play pivotal roles in the antitumor effects of immune checkpoint inhibitors (ICIs). However, antimicrobial therapy, often necessary for infections in cancer patients, can reduce the efficacy of ICIs. The potential of probiotics to restore ICI efficacy remains uncertain.
View Article and Find Full Text PDFEffects of synbiotics surpass probiotics alone in improving type 2 diabetes mellitus: A randomized, double-blind, placebo-controlled trial.
Clin Nutr
December 2024
Department of Nutrition and Health, Key Laboratory of Functional Dairy, Co-constructed by Ministry of Education and Beijing Government, China Agricultural University, Beijing 100193, China. Electronic address:
Background And Aims: Combining probiotics and prebiotics in synbiotics may present a synergistic approach to improve type 2 diabetes mellitus (T2DM); however, further evidence is required to establish the comparative efficacy of synbiotics versus probiotics. This study aimed to evaluate the effects of Bifidobacterium animalis subsp. lactis MN-Gup (MN-Gup) and a synbiotic mixture of MN-Gup and galactooligosaccharide (MN-Gup-GOS) on glycemic control in T2DM patients and explore possible mechanisms.
View Article and Find Full Text PDFPreventive effect of Clostridium butyricum MIYAIRI against pouchitis in children with ulcerative colitis.
Surg Today
December 2024
Department of Gastrointestinal and Pediatric Surgery, Mie University Graduate School of Medicine, Edobashi 2-174, Tsu, Mie, 514-8507, Japan.
Purpose: Pouchitis is a major complication after ileal pouch-anal anastomosis (IPAA) for ulcerative colitis in children (UCc). In this study, we investigated whether the oral administration of Clostridium butyricum MIYAIRI 588 (CBM) can reduce the incidence of pouchitis after IPAA in UCc.
Methods: We reviewed the data for pediatric patients with UC, who underwent IPAA in Mie University Hospital between 2004 and 2022.
Bacillus subtilis Intraspecies Interactions Shape Probiotic Activity Against Salmonella Typhimurium.
Microb Biotechnol
December 2024
Department of Microbiology, Biotechnical Faculty, University of Ljubljana, Ljubljana, Slovenia.
Commercial probiotics are often formulated as multi-strain cocktails, but the effects of social interactions, particularly between strains of a species, are often neglected, despite their potential to contribute to higher-order interactions where these interactions could affect those with a third party. In this study, we investigated the probiotic potential of a collection of Bacillus subtilis strains against Salmonella Typhimurium in single-strain and mixed cultures. The results indicate a promising probiotic potential of B.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!