Objective: To evaluate whether having a cleft palate with or without cleft lip (CP ± L) influences the performance of a child on a wind instrument.
Design: Cross-sectional.
Setting: This study was conducted at Asociación San Lucas (Peru), which has a multidisciplinary care program for children with CP ± L. Free recorder lessons are offered to all patients aged 6-8 years. After that, the children can switch to flute, clarinet, violin, viola, or cello. For a fee, children without CP ± L can also participate in the music program.
Participants: All children with and without CP ± L who were participating in the music program and were able to play the recorder, flute, or clarinet (N = 43).
Main Outcome Measures: Quantitative and qualitative performance exercises: maximum blowing duration, highest note, lowest note, diminuendo, crescendo, and sound quality.
Results: No significant differences in performance were found between children with and without CP ± L. Older children and children with more experience on their instrument demonstrated a significantly longer blowing duration and better sound quality. Within the CP ± L group, those with a satisfactory surgery result had a significantly longer blowing duration than those with a partly satisfactory result (eg, presence of a fistula, palatal surgery revisions, or (need of) pharingoplasty). Furthermore, children with bilateral cleft lip and palate performed diminuendo significantly less smoothly than those with the unilateral type.
Conclusion: Children with and without CP ± L demonstrated equally good performances on the recorder, flute, and clarinet. Therefore, families and caregivers should not discourage children with CP ± L from learning to play these wind instruments.
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http://dx.doi.org/10.1177/10556656241290432 | DOI Listing |
Neoplasia
December 2024
Felsenstein Medical Research Center, Beilinson Campus, Petah Tikva, Israel; Tel Aviv University, Faculty of Medicine and Health Sciences, Tel Aviv, Israel; Rabin Medical Center, Beilinson Campus, Petah Tikva, Israel; Davidoff Cancer Center, Beilinson Campus, Petah Tikva, Israel. Electronic address:
Triple-negative breast cancer (TNBC) is an aggressive subtype that accounts for 10-15 % of breast cancer. Current treatment of high-risk early-stage TNBC includes neoadjuvant chemo-immune therapy. However, the substantial variation in immune response prompts an urgent need for new immune-targeting agents.
View Article and Find Full Text PDFJ Acquir Immune Defic Syndr
December 2024
Departments of Epidemiology and Anthropology, University of Washington, Seattle, WA, USA.
Background: Most infants born to women living with HIV (WLH) are HIV-exposed but uninfected exposed infants have poorer growth than HIV-unexposed uninfected children. Few large studies have compared children who are exposed (CHEU) and unexposed (CHUU) in the era of dolutegravir (DTG)-based antiretroviral treatment (ART).
Setting: Longitudinal study of mother-infant CHEU and CHUU pairs in Nairobi and Western Kenya.
JBJS Case Connect
October 2024
Department of Pediatric Orthopaedic Surgery, Hospital for Special Surgery, New York, New York.
Case: A pediatric patient with focal fibrocartilaginous dysplasia (FFCD) developed angular deformity and growth arrest despite standard guided growth management. The patient underwent implant-mediated guided growth for proximal tibia varus deformity which recurred; subsequently, a physeal bar of the medial proximal tibia was diagnosed, which progressed to physeal arrest.
Conclusion: Treatment options for FFCD-associated angular deformity include observation and guided growth.
Neurology
January 2025
Faculty of Medicine, University of Geneva, Switzerland.
Early detection of focal cortical dysplasia (FCD) using brain MRI in young children presenting with drug-resistant epilepsy may facilitate prompt surgical treatment, resulting in better control of seizures and decreased associated cognitive difficulties. Characteristics of FCD described in the literature are predominantly based on MRI findings in a fully myelinated brain; therefore, changes occurring during early brain maturation are not well known. In this case report, we describe distinct MRI features of a FCD visualized best before completion of myelination of the cortex and subcortical white matter.
View Article and Find Full Text PDFClin J Sport Med
October 2024
Sports Medicine and Orthopaedics, Children's Health Andrews Institute, Plano, Texas.
Objective: To examine differences in the presentation and management of concussion in younger children (aged 4-8 years) versus preadolescents (9-12 years) and identify factors that influence recovery time.
Design: Retrospective analysis of prospectively collected data.
Setting: Pediatric sports medicine and orthopedics clinic.
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