Dimensionality reduction is a method used in machine learning and data science to reduce the dimensions in a dataset. While linear methods are generally less effective at dimensionality reduction than nonlinear methods, they can provide a linear relationship between the original data and the dimensionality-reduced representation, leading to better interpretability. In this research, we present a tied-weight autoencoder as a dimensionality reduction model with the merit of both linear and nonlinear methods. Although the tied-weight autoencoder is a nonlinear dimensionality reduction model, we approximate it to function as a linear model. This is achieved by removing the hidden layer units that are largely inactivated by the input data, while preserving the model's effectiveness. We evaluate the proposed model by comparing its performance with other linear and nonlinear models using benchmark datasets. Our results show that the proposed model performs comparably to the nonlinear model of a similar autoencoder structure to the proposed model. More importantly, we show that the proposed model outperforms the linear models in various metrics, including the mean square error, data reconstruction, and the classification of low-dimensional projections of the input data. Thus, our study provides general recommendations for best practices in dimensionality reduction.
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http://dx.doi.org/10.1038/s41598-024-77080-8 | DOI Listing |
Phys Rev Lett
December 2024
Harish-Chandra Research Institute, A CI of Homi Bhabha National Institute, Chhatnag Road, Jhusi, Allahabad 211019, India.
Pump-probe response of the spin-orbit coupled Mott insulator Sr_{2}IrO_{4} reveals a rapid creation of low-energy optical weight and suppression of three-dimensional magnetic order on laser pumping. Postpump there is a quick reduction of the optical weight but a very slow recovery of the magnetic order-the difference is attributed to weak interlayer exchange in Sr_{2}IrO_{4} delaying the recovery of three-dimensional magnetic order. We suggest that the effect has a very different and more fundamental origin.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Queen Mary University of London, London, London, United Kingdom.
Background: Recent studies suggest the existence of distinct molecular subtypes within the AD patient cohort, characterized by distinct gene expression patterns in AD-relevant genes and pathways. Understanding these putative subtypes may prove pivotal to the greater understanding of AD pathology and developing targeted therapeutic interventions. This study aims to extend existing research by employing omics data modalities beyond gene expression, gathered from the ROSMAP and MSBB Alzheimer's studies.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
MRC Unit for Lifelong Health and Ageing at UCL, London, United Kingdom.
Background: Dementia-related biomarkers can detect pathology years before clinical diagnostic criteria are met. Understanding the relationship between biomarkers and early cognitive changes is crucial as disease-modifying therapies may have maximum benefits when delivered early. We aimed to demonstrate the utility of remote computerised cognitive tests in a large cohort of cognitively normal older individuals, comparing these to standard in-person assessments and investigating their associations with biomarkers.
View Article and Find Full Text PDFSAR QSAR Environ Res
November 2024
Research and Development Center, Bioinnov Solutions LLP, Salem, India.
Hepatocellular carcinoma (HCC) ranks fourth in cancer-related mortality worldwide. This study aims to uncover the genes and pathways involved in HCC through network pharmacology (NP) and to discover potential drugs via machine learning (ML)-based ligand screening. Additionally, toxicity prediction, molecular docking, and molecular dynamics (MD) simulations were conducted.
View Article and Find Full Text PDFAesthet Surg J
January 2025
Department of Plastic and Reconstructive Surgery, Brussels University Hospital - Vrije Universiteit Brussel (VUB), Brussels, Belgium.
Background: Three-dimensional (3D) imaging enhances surgical planning and documentation in plastic surgery, but high costs limit accessibility. Mobile Light Detection and Ranging (LiDAR) technology offers a potential cost-effective alternative.
Objectives: To evaluate the accuracy and clinical utility of iPhone-based LiDAR scanning for breast measurements compared to traditional methods, and to establish standardized protocols for clinical implementation.
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