AI Article Synopsis
- * Findings showed that higher genetically predicted BMI and WHRadjBMI were linked to non-alcoholic fatty liver disease, liver fibrosis, and autoimmune hepatitis, but not to other liver conditions like primary biliary cholangitis or liver cancer.
- * The research suggested that obesity has distinct causal effects on certain liver diseases and metabolic functions, particularly non-alcoholic fatty liver disease and liver fibrosis, but not on viral or autoimmune liver diseases.
Article Abstract
The associations between obesity and liver diseases are complex and diverse. To explore the causal relationships between obesity and liver diseases, we applied two-sample Mendelian randomisation (MR) and multivariable MR analysis. The data of exposures (BMI and WHRadjBMI) and outcomes (liver diseases and liver function biomarker) were obtained from the open genome-wide association study database. A two-sample MR study revealed that the genetically predicted BMI and WHRadjBMI were associated with non-alcoholic fatty liver disease, liver fibrosis and autoimmune hepatitis. Obesity was not associated with primary biliary cholangitis, liver failure, liver cell carcinoma, viral hepatitis and secondary malignant neoplasm of liver. A higher WHRadjBMI was associated with higher levels of biomarkers of lipid accumulation and metabolic disorders. These findings indicated independent causal roles of obesity in non-alcoholic fatty liver disease, liver fibrosis and impaired liver metabolic function rather than in viral or autoimmune liver disease.
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| http://dx.doi.org/10.1017/S000711452400237X | DOI Listing |
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