Purpose: This study aimed to characterize core-temperature (Tc) responses of swimmers competing at the 2024 3-km World Aquatics Masters Open Water Swimming Championships.
Methods: Within a cross-sectional observational study design, swimmers (n = 48 [23 male, 25 female]) ingested a telemetric Tc pill 4 hours before their race. Water temperatures were 20.9 °C (male; mean wet-bulb-globe temperature 25.9 °C) and 20.5 °C (female; mean wet-bulb-globe temperature: 25.4 °C). Linear mixed models determined differences between males and females for race-start, mean in-race, and peak Tc. Random coefficient models determined relationships between (1) sex, race time, body mass index (BMI), body-mass change or age, and Tc peak; (2) sex, race time, BMI, body-mass change or age, and Tc nadir; (3) sex, Tc peak, BMI, body-mass change or age, and race time, and (4) sex, Tc peak, BMI, body-mass change, or age and race ranking.
Results: The mean in-race Tc was 37.8 °C (36.1-38.8 °C); however, there were highly variable individual Tc responses (-3.1 to +2.7 °C). One swimmer experienced mild hypothermia (Tc ≤ 35.0 °C), and 5 exceeded 39.0 °C, a risk factor for heat-related illness. There were no statistical differences between males and females for race-start, mean, and peak Tc (P ≥ .243). Higher peak Tc was associated with faster race time (P = .05), higher race rank (P = .027), and higher BMI (P = .001).
Conclusions: Highly variable Tc responses (-3.1 to +2.7 °C) were observed, demonstrating that organizers of mass-participation open-water swimming events should always be prepared for, and provide facilities to treat, swimmers experiencing cold-/heat-related health incidents during competition.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1123/ijspp.2024-0240 | DOI Listing |
AAPS J
January 2025
Clinical Pharmacology Modeling and Simulation, Amgen, One Amgen Center Drive, Thousand Oaks, CA, 91320-0777, USA.
Sotorasib is a novel KRAS inhibitor that has shown robust efficacy, safety, and tolerability in patients with KRAS mutation. The objectives of the population pharmacokinetic (PK) analysis were to characterize sotorasib population PK in healthy subjects and patients with advanced solid tumors with KRAS mutation from 6 clinical studies, evaluate the effects of intrinsic and extrinsic factors on PK parameters, and perform simulations to further assess the impact of identified covariates on sotorasib exposures. A two-compartment disposition model with three transit compartments for absorption and time-dependent clearance and bioavailability well described sotorasib PK.
View Article and Find Full Text PDFAnn Intern Med
January 2025
Division of Thoracic Surgery and Interventional Pulmonology, Swedish Cancer Institute, Seattle, Washington (C.L.W., A.C.W., J.A.G.).
Background: The U.S. Preventive Services Task Force recommends annual lung cancer screening (LCS) for adults who meet specific age and smoking history criteria.
View Article and Find Full Text PDFIntroduction: Patients undergoing hip fracture surgery face notable risks of postoperative morbidity and mortality, and racial and socioeconomic disparities in outcomes exist. This study examined the effect of social vulnerability on outcomes after hip fracture surgery using the CDC's Social Vulnerability Index (SVI).
Methods: A retrospective study of 464 patients undergoing hip fracture surgery at a single institution from July 2020 to June 2023 was conducted.
Hepatology
January 2025
School of Medicine, Institute of Human Genetics, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.
JAMA Pediatr
January 2025
Department of Cardiology, Harvard Medical School and Boston Children's Hospital, Boston, Massachusetts.
Importance: Multisystem inflammatory syndrome in children (MIS-C) is a life-threatening complication of COVID-19 infection. Data on midterm outcomes are limited.
Objective: To characterize the frequency and time course of cardiac dysfunction (left ventricular ejection fraction [LVEF] <55%), coronary artery aneurysms (z score ≥2.
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!