Relatively little is known about the innate surgical ability of veterinary undergraduates. The objective of this study was to investigate if there were differences in the innate surgical ability of a cohort of 142 third-year veterinary undergraduate students to perform a series of simulated orthopedic surgical tasks, and whether specific factors influenced their innate ability. Participants performed four simulated surgical tasks; "depth of plunge"-an assessment of the "plunge" depth through foam when drilling through the trans cortex of a PVC pipe; "3-dimensional drilling"-an assessment of accuracy when drilling through a block of wood; "depth measurement"-an assessment of the ability to correctly measure the depth of holes in PVC pipe; and "fracture reduction"-where the speed and systematic reduction of a simulated fracture was assessed using a rubric score. Performance for each task was compared based on the responses to a survey. Results showed considerable variation in innate ability. Previous experience performing manual tasks and using a drill was associated with an improvement in students' ability to perform one of the four tasks (fracture reduction). Age, gender, handedness, videogame experience, building game experience, exposure to orthopedic surgery, or desire to pursue surgery as a career were not associated with student performance in any task. A learning curve was observed for the depth of plunge task. An increased target angle led to decreased drilling accuracy for the 3D drilling task. The innate ability of veterinary students to undertake simulated surgical tasks was largely unaffected by the previous experiences evaluated.
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http://dx.doi.org/10.3138/jvme-2023-0072 | DOI Listing |
J Biol Chem
December 2024
Department of Molecular Medicine, College of Veterinary Medicine, Cornell University, Ithaca, NY, 14853, USA; Department of Chemistry and Chemical Biology, Cornell University, Ithaca, NY, 14853, USA. Electronic address:
Phosphatase and Tensin Homologue (PTEN) is one of the most frequently lost tumor suppressors in cancer and the predominant negative regulator of the PI3K/AKT signaling axis. A growing body of evidence has highlighted the loss of PTEN with immuno-modulatory functions including the upregulation of the programmed death ligand-1 (PD-L1), an altered tumor derived secretome that drives an immunosuppressive tumor immune microenvironment (TIME), and resistance to certain immunotherapies. Given their roles in immunosuppression and tumor growth, we examined whether the loss of PTEN would impact the biogenesis, cargo, and function of extracellular vesicles (EVs) in the context of the anti-tumor associated cytokine interferon-γ (IFN-γ).
View Article and Find Full Text PDFAppl Microbiol Biotechnol
December 2024
Biotechnical Faculty, Department of Food Science and Technology, University of Ljubljana, Ljubljana, Slovenia.
Campylobacter jejuni, a major cause of foodborne zoonotic infections worldwide, shows a paradoxical ability to survive despite its susceptibility to environmental and food-processing stressors. This resilience is likely due to the bacterium entering a viable but non-culturable state, often within biofilms, or even initiating biofilm formation as a survival strategy. This study presents an innovative application of NanoLuc bioluminescence to accurately monitor the development of C.
View Article and Find Full Text PDFParasitol Res
December 2024
Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, ON, Canada.
Coccidiosis is caused by apicomplexan parasites of the genus Eimeria, which infect epithelial cells of the intestinal tract causing diarrhea and negatively impacting production in the poultry industry. The self-limiting and highly immunogenic nature of infection by Eimeria spp. make live vaccination an effective means of coccidiosis control.
View Article and Find Full Text PDFMicrob Pathog
December 2024
Freie Universität Berlin, Institute for Parasitology and Tropical Veterinary Medicine, Berlin, Germany; Freie Universität Berlin, Veterinary Centre for Resistance Research, Berlin, Germany. Electronic address:
Reversible transformation of bovine leukocytes by the intracellular parasites Theileria annulata and Theileria parva is central to pathogenesis of the diseases they cause, tropical theileriosis and East Coast Fever, respectively. Parasite-dependent constitutive activation of major host transcription factors such as AP-1 (Activating Protein 1) and NF-κB (Nuclear Factor-Kappa B) sustains the transformed state. Although parasite interaction with host cell signaling pathways upstream of AP-1 have been studied, the precise contribution of Theileria encoded factors capable of modulating AP-1 transcriptional activity, and other infection-altered signaling pathways is not fully understood.
View Article and Find Full Text PDFFood Chem
December 2024
Research Faculty and Graduate School of Agriculture, Hokkaido University, Sapporo, 060-8589, Japan. Electronic address:
To clarify the cause of graded distribution of sucrose in apple fruit flesh, a quarter cut of young apple fruit was cultured for 72 h on agar-solidified MS medium supplemented with 0.5 M [1-C]sorbitol, with the longitudinal or horizontal cut face being attached with the medium, and distribution of C-labelled sucrose in a specimen obtained by slicing the fruit along with the cut face was visualized utilizing MALDI-TOF MSI. Heat map images on the distribution of the peaks of sorbitol containing C-atom indicated that external [1-C]sorbitol had penetrated evenly into the tissue.
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