Spotlight on Amniotic Membrane Extract Eye Drops: A Review of the Literature.

Eye Contact Lens

Department of Translational Medicine (R.K., V.D.R.), University of Ferrara, Ferrara, Italy; Department of Ophthalmology (R.K., V.D.R.), Ospedali Privati Forlì "Villa Igea", Forlì, Italy; Department of Neurosciences, Biomedicine and Movement Sciences (E.B., C.R., E.P., G.M.), Ophthalmic Unit, University of Verona, Verona, Italy; Department of Ophthalmology and Optometry (R.D., J.L., G.S.), Medical University of Vienna, Vienna, Austria; and Ophthalmology Unit (E.C.), "Fondazione Policlinico Universitario a. Gemelli IRCCS", Rome, Italy.

Published: November 2024

AI Article Synopsis

  • The review aimed to assess how effective amniotic membrane extract eye drops (AMEDs) are in treating ocular surface diseases by analyzing existing literature.
  • After searching major databases, 12 out of 1,121 initial studies were deemed suitable for analysis, covering various clinical outcomes and methods of preparation for AMEDs.
  • The findings suggest that while evidence quality is not perfect, AMEDs provide improvements for patients with conditions like dry eye disease and corneal wounds, reporting a low incidence of side effects.

Article Abstract

Objective: To review the literature focusing on the effectiveness of amniotic membrane extract eye drops (AMEDs) in the treatment of ocular surface diseases.

Methods: PubMed/MEDLINE, Scopus, and CENTRAL databases were searched until March 4, 2024. Overall, we identified 1,121 studies, 26 of which were selected for a full-text review. Twelve studies met the inclusion criteria and were analyzed for clinical improvements, time to resolution of corneal staining, adverse events, and preparation methods. Strength of clinical data was graded according to the Oxford Center for Evidence-Based Medicine.

Results: Overall, AMED compounds were used in 296 eyes of 205 patients. Fifty-nine percent of eyes were treated for dry eye disease, 23% for an epithelial defect, and the rest (18%) for other corneal wound healing disorders. Three main types of eye drops preparation were described, that is, lyophilized, homogenized, and fresh AMED. Although the methods of outcome reporting were heterogeneous, all included studies showed various grades of improvement in both signs and symptoms. The overall incidence of ocular side effects was 2.3%.

Conclusions: Despite the suboptimal quality of evidence, overall, the available literature suggests that AMED is a valuable tool in the treatment of ocular surface disorders.

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Source
http://dx.doi.org/10.1097/ICL.0000000000001136DOI Listing

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