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Advancements in bispecific antibodies for multiple myeloma: What's new and what lies ahead.
Semin Hematol
December 2024
Division of Hematology and Medical Oncology, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY. Electronic address:
Recent advancements in multiple myeloma (MM) treatment-including immunomodulatory drugs, proteasome inhibitors, monoclonal antibodies, and T cell-redirecting therapies like chimeric antigen receptor (CAR) T cells and bispecific antibodies (BsAbs)-have significantly improved patient outcomes. However, MM remains incurable, highlighting the need for novel therapeutic strategies. BsAbs, which simultaneously target a tumor-specific antigen and CD3 on T cells, have shown promising efficacy.
View Article and Find Full Text PDFSupporting contraceptive self-care and reproductive empowerment with a digital health game in Barbados: Development and Pre-implementation study for What's My Method?
Gates Open Res
January 2025
Barbados Family Planning Association, Bridgetown, Saint Michaels, Barbados.
Effective contraceptive education is essential to reducing unwanted pregnancy, increasing uptake of modern contraceptive methods, and thoughtfully planning desired births. New World Health Organization (WHO) and family planning organization guidelines recommend situating contraceptive education and counseling within a broader context of self-care that emphasizes individual agency and reproductive empowerment. Digital health interventions, and games for health specifically, have been validated as effective and scalable tools for self-guided and interactive health education, especially among younger tech-savvy individuals.
View Article and Find Full Text PDFProblems with experimental reproducibility affect every field of science. However, the opinions on the causes of the reproducibility “crisis” and how we all can help vary amongst fields as well as individual scientists. Here, we talk to experts from different fields of science to get their insights on this endemic issue.
View Article and Find Full Text PDFAnd after surgery, what's new for the rectal cancer survivor?
Cir Esp (Engl Ed)
January 2025
Unidad de Cirugía Colorrectal, Servicio de Cirugía General y Digestiva, Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain.
Low anterior resection syndrome is a common but underestimated complication after rectal cancer surgery that significantly impacts the quality of life of the surviving patient. It is characterized by symptoms such as fecal incontinence and voiding dysfunction and affects up to 90% of patients undergoing low anterior rectal resection. The etiology of the syndrome is multifactorial with no clear determining factor.
View Article and Find Full Text PDFWhat's causing this new mother's depressed mood?
JAAPA
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Jessica G. Sheehan practices in neurosurgery at Palo Alto Medical Foundation's Mountain View Center in Mountain View, Calif. The author has disclosed no potential conflicts of interest, financial or otherwise.
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