Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11532220 | PMC |
| http://dx.doi.org/10.1016/j.gendis.2024.101261 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
EBF1 expressed in the dermal papilla regulates hair type and length.
Genes Dis
January 2025
School of Life Sciences, Shanghai University, Shanghai 200444, China.
The dynamic N-methyladenosine RNA methylation provides insights into the tomato fruit ripening.
Plant J
December 2024
Institute of Agri-food Processing and Nutrition, Beijing Academy of Agriculture and Forestry Sciences, Beijing Key Laboratory of Fruits and Vegetable Storage and Processing, Key Laboratory of Vegetable Postharvest Processing of Ministry of Agriculture and Rural Areas, State Key Laboratory of Vegetable Biobreeding, Beijing Vegetable Research Center, Beijing Academy of Agriculture and Forestry Science, Beijing, 100097, China.
N-methyladenosine (mA) methylation is an essential mechanism of gene regulation known to impact several biological processes in living organisms. However, little is known about the abundance, distribution, and functional significance of mRNA mA modification during fruit ripening of tomato the main model species for fleshy fruits. Our study shows that mA modifications are prevalent in tomato mRNA and are detected in lncRNA and circRNA.
View Article and Find Full Text PDFBenchmarking and building DNA binding affinity models using allele-specific and allele-agnostic transcription factor binding data.
Genome Biol
October 2024
Department of Biological Sciences, Columbia University, New York, NY, 10027, USA.
Background: Transcription factors (TFs) bind to DNA in a highly sequence-specific manner. This specificity manifests itself in vivo as differences in TF occupancy between the two alleles at heterozygous loci. Genome-scale assays such as ChIP-seq currently are limited in their power to detect allele-specific binding (ASB) both in terms of read coverage and representation of individual variants in the cell lines used.
View Article and Find Full Text PDFDihydroartemisinin Modulates Prostate Cancer Progression by Regulating Multiple Genes via the Transcription Factor NR2F2.
Curr Pharm Biotechnol
October 2024
Department of Surgery, Suihua Hospital of Traditional Chinese Medicine, Suihua, HeiLongJiang, 152000, China.
Objective: This study aimed to investigate the effect of dihydroartemisinin (DHA) on DU145 cells and the role of NR2F2 (COUP-TFII) and its potential target genes in this process.
Methods: GSE122625 was used to identify differentially expressed genes (DEGs) between the DHA-treated and control groups. Protein-protein interaction (PPI) network analysis was performed to identify hub genes, and the ChEA3 database was used to identify potential transcription factors.
Epigenomic and Transcriptomic Profiling of Solitary Fibrous Tumors Identifies Site-Specific Patterns and Candidate Genes Regulated by DNA Methylation.
Lab Invest
November 2024
Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada; Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Ontario, Canada. Electronic address:
Article Synopsis
- Solitary fibrous tumor (SFT) is a rare type of tumor that can occur in various body parts and is often linked to specific genetic fusions, with 10-30% of cases becoming metastatic.
- A study involving DNA methylation analysis of 79 SFTs revealed distinct epigenetic changes linked to their primary sites, identifying key genes such as EGFR and TBX15 that showed differing levels of expression based on the tumor's location and genetic fusion type.
- TBX15 emerged as a significant marker, with changes in its methylation and expression strongly correlating to the tumor's tissue of origin, suggesting it could help differentiate between new tumors and metastases without needing extensive genomic analysis.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!