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Exosome-based cell therapy for diabetic foot ulcers: Present and prospect. | LitMetric

Exosome-based cell therapy for diabetic foot ulcers: Present and prospect.

Heliyon

Department of Endocrinology and Metabolism, School of Medicine, Chongqing University Central Hospital, Chongqing Emergency Medical Center, Chongqing, 400014, China.

Published: October 2024

AI Article Synopsis

  • * Current treatments for DFUs are difficult, prompting the need for innovative solutions like cell-free therapies, particularly using exosomes, which aid in various healing processes.
  • * This review highlights the mechanisms of exosomes in wound healing, addresses challenges in clinical use, and discusses the potential benefits of exosome mimics in treating DFUs.

Article Abstract

Diabetic foot ulcers (DFUs) represent a serious complication of diabetes with high incidence, requiring intensive treatment, prolonged hospitalization, and high costs. It poses a severe threat to the patient's life, resulting in substantial burdens on patient and healthcare system. However, the therapy of DFUs remains challenging. Therefore, exploring cell-free therapies for DFUs is both critical and urgent. Exosomes, as crucial mediators of intercellular communication, have been demonstrated potentially effective in anti-inflammation, angiogenesis, cell proliferation and migration, and collagen deposition. These functions have been proven beneficial in all stages of diabetic wound healing. This review aims to summarize the role and mechanisms of exosomes from diverse cellular sources in diabetic wound healing research. In addition, we elaborate on the challenges for clinical application, discuss the advantages of membrane vesicles as exosome mimics in wound healing, and present the therapeutic potential of exosomes and their mimetic vesicles for future clinical applications.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11532254PMC
http://dx.doi.org/10.1016/j.heliyon.2024.e39251DOI Listing

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