A crystal structure is no longer conceived as a static entity; rather, it often mirrors crystallization pathways, linking crystal structures with a solution scenario. In this study, taking a clue from a previously reported ionic cocrystal structure, an acetic acid-based catalytic protocol is developed for the -acylation of amines using ester sources. In addition to better catalytic efficiency, this approach was extended further to a mechanochemistry protocol in the context of a multicomponent reaction. This points towards a broader applicability of crystal structures that goes beyond the domain of structural chemistry and delves into catalysis and mechanosynthesis.
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| http://dx.doi.org/10.1039/d4ra05652c | DOI Listing |
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