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Patient-centered outcomes for clinical trials in chronic rhinosinusitis with or without nasal polyps and allergic fungal rhinosinusitis.
J Patient Rep Outcomes
January 2025
Sanofi US Services, Inc., Bridgewater, NJ, USA.
Background: Chronic rhinosinusitis (inclusive of subtypes with nasal polyps [CRSwNP], without nasal polyps [CRSsNP], and allergic fungal rhinosinusitis [AFRS]) causes inflammation of the nose mucosa and paranasal sinuses. Unfortunately, evidence supporting use of clinical outcome assessments (COAs) in regulated clinical trials to assess key measurement concepts of these conditions is limited.
Objective: To identify key disease-related symptoms and impacts, potential outcomes of interest for new treatments, and COAs available to measure those outcomes among adult and adolescent individuals living with CRSwNP, CRSsNP, and AFRS.
Chronic rhinosinusitis with nasal polyps (CRSwNP) symptom verbal response scales: content validity testing for use in adults with CRSwNP.
J Patient Rep Outcomes
December 2024
Patient-Centered Outcomes, Adelphi Values, Bollington, Cheshire, UK.
Background: PRO measures of symptoms in clinical trials have historically utilized visual and numerical scales but verbal descriptors may make it easier for patients to clearly differentiate between response options. This study assessed content validity and meaningful change in five verbal response scales (VRSs) used to assess chronic rhinosinusitis with nasal polyp (CRSwNP) symptom severity.
Methodology: This qualitative, semi-structured interview study recruited adults from the US, Germany, and China with confirmed moderate-to-severe CRSwNP.
Factors influencing the course of post-COVID-19-related symptoms: A bidirectional cohort study among employees in health and welfare services in Germany.
GMS Hyg Infect Control
November 2024
Competence Center for Epidemiology and Health Services Research for Healthcare Professionals (CVcare), Institute for Health Services Research in Dermatology and Nursing (IVDP), University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany.
Objective: The aim of this study was to determine the prevalence and trajectory of persistent symptoms following COVID-19 and to investigate factors influencing these among employees in the health and welfare services in Germany.
Methods: This exploratory, mixed retro- and prospective cohort study using paper-and-pencil questionnaires was conducted among insured persons of the German Social Accident Insurance Institution for the health and welfare services with a SARS-CoV-2 infection in 2020. The baseline survey in February 2021 was succeeded by two follow-up surveys after 8 and 13 months.
Medication safety with oral antitumour therapeutics in paediatrics (youngAMBORA): A mixed-methods approach towards a tailored care program.
PLoS One
December 2024
Comprehensive Cancer Center Erlangen-EMN, Universitätsklinikum Erlangen, Erlangen, Germany.
Article Synopsis
- - The AMBORA trial showed the benefits of a pharmacological care program for adults using oral antitumour therapeutics (OAT), but similar tailored support for pediatric patients was lacking, leading to the development of the youngAMBORA program.
- - This program was designed using both quantitative data on the types of cancers and OAT used in a pediatric cancer center, and qualitative surveys to gauge the needs of patients, caregivers, and healthcare providers regarding medication application and side effects.
- - Key findings revealed that leukemia is common among pediatric patients, with many expressing a desire for education about oral medication; the program will provide counseling, child-friendly medication support, and evaluate 17 relevant side effects, including some previously unrecognized. *
'Incense is the one that keeps the air fresh': indoor air quality perceptions and attitudes towards health risk.
BMC Public Health
November 2024
School of Public Health, Imperial College London, London, UK.
Background: Air pollution is of significant environmental and public health concern globally. While much research has historically focused on outdoor air pollution, indoor air pollution has been relatively under-explored despite its strong connection with health outcomes, particularly respiratory health. Studies on air pollution exposure mitigation consistently reveal a significant knowledge gap between the understanding of air pollution as a health risk among lay individuals and expert scientists.
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