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Manifestations of Head and Neck Cancer in Patients With Plummer-Vinson Syndrome: A Systematic Review.
Oral Dis
January 2025
Department of Stomatologic Sciences, School of Dentistry, Federal University of Goiás, Goiânia, Goiás, Brazil.
Objective: To investigate the clinical manifestations of head and neck cancer in patients with Plummer-Vinson syndrome (PVS) and to assess related oral comorbidities.
Materials And Methods: Case reports covering head and neck cancer manifestations in patients diagnosed with PVS were included Studies were identified through seven main electronic databases (PubMed/MEDLINE, EMBASE, Scopus, Web of Science, CINAHL, LILACS, and LIVIVO), and a search for gray literature was performed using ProQuest Dissertations and Theses and Google Scholar. Independent reviewers applied predefined eligibility criteria in a two-phase selection process.
Calcium channels as therapeutic targets in head and neck squamous cell carcinoma: current evidence and clinical trials.
Front Oncol
December 2024
Department of Otolaryngology, Longgang Otolaryngology hospital & Shenzhen Key Laboratory of Otolaryngology, Shenzhen Institute of Otolaryngology, Shenzhen, China.
Head and neck squamous cell carcinoma (HNSCC) originates from the mucosal epithelium of the oral cavity, pharynx, and larynx, and is marked by high rates of recurrence and metastasis. Calcium signaling is associated with the progression of HNSCC and the development of drug resistance. Changes in calcium ion flow can trigger severe pathophysiological processes, including malignant transformation, tumor proliferation, epithelial-mesenchymal transition, and apoptosis evasion.
View Article and Find Full Text PDFXerostomia: a silent burden for people receiving palliative care - a qualitative descriptive study.
BMC Palliat Care
January 2025
Kerry Specialist Palliative Care Service, University Hospital Kerry, Tralee, Co. Kerry, Ireland.
Background: The prevalence of dry mouth in the palliative care population is well documented and increases due to polypharmacy, radiotherapy and systemic conditions. Saliva as a lubricant for the mouth and throat has implications for swallowing, chewing, and speech. The literature about the experience of xerostomia (perceived feeling of dry mouth) in palliative care is scarce.
View Article and Find Full Text PDFSegmentation aware probabilistic phenotyping of single-cell spatial protein expression data.
Nat Commun
January 2025
Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, ON, Canada.
Spatial protein expression technologies can map cellular content and organization by simultaneously quantifying the expression of >40 proteins at subcellular resolution within intact tissue sections and cell lines. However, necessary image segmentation to single cells is challenging and error prone, easily confounding the interpretation of cellular phenotypes and cell clusters. To address these limitations, we present STARLING, a probabilistic machine learning model designed to quantify cell populations from spatial protein expression data while accounting for segmentation errors.
View Article and Find Full Text PDFRecurrent Pleomorphic Adenoma Presenting as a Giant Parapharyngeal Mass.
Ear Nose Throat J
January 2025
Department of Otolaryngology-Head and Neck Surgery, Al-Bairuni University Hospital, Faculty of Medicine, Damascus University, Damascus, Syria.
Article Synopsis
- Pleomorphic adenoma (PA) is a common benign tumor of the salivary glands, often recurs and can extend into the parapharyngeal space (PPS), complicating treatment.
- A 45-year-old male with a history of limited PA excision presented with a growing neck mass and related symptoms; MRI revealed a large tumor in the PPS.
- Surgical removal involved a specialized neck approach, and the patient received postoperative radiotherapy, emphasizing the complexities and careful planning required for effective management of PPS tumors.
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