A PHP Error was encountered

Severity: Warning

Message: fopen(/var/lib/php/sessions/ci_sessioncru39ii9jrv2hqn3caju89kesstaia5v): Failed to open stream: No space left on device

Filename: drivers/Session_files_driver.php

Line Number: 177

Backtrace:

File: /var/www/html/index.php
Line: 316
Function: require_once

A PHP Error was encountered

Severity: Warning

Message: session_start(): Failed to read session data: user (path: /var/lib/php/sessions)

Filename: Session/Session.php

Line Number: 137

Backtrace:

File: /var/www/html/index.php
Line: 316
Function: require_once

A PHP Error was encountered

Severity: Warning

Message: file_get_contents(https://...@gmail.com&api_key=61f08fa0b96a73de8c900d749fcb997acc09): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests

Filename: helpers/my_audit_helper.php

Line Number: 143

Backtrace:

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 143
Function: file_get_contents

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 209
Function: simplexml_load_file_from_url

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 3098
Function: getPubMedXML

File: /var/www/html/application/controllers/Detail.php
Line: 574
Function: pubMedSearch_Global

File: /var/www/html/application/controllers/Detail.php
Line: 488
Function: pubMedGetRelatedKeyword

File: /var/www/html/index.php
Line: 316
Function: require_once

A PHP Error was encountered

Severity: Warning

Message: Attempt to read property "Count" on bool

Filename: helpers/my_audit_helper.php

Line Number: 3100

Backtrace:

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 3100
Function: _error_handler

File: /var/www/html/application/controllers/Detail.php
Line: 574
Function: pubMedSearch_Global

File: /var/www/html/application/controllers/Detail.php
Line: 488
Function: pubMedGetRelatedKeyword

File: /var/www/html/index.php
Line: 316
Function: require_once

Longitudinal Changes in Choroidal Thickness and Choroidal Vascularity Index in Age-Related Macular Degeneration. | LitMetric

AI Article Synopsis

  • - The study aimed to assess how choroidal thinning and the Choroidal Vascularity Index (CVI) change over time in patients with various stages of age-related macular degeneration (AMD) compared to healthy individuals.
  • - Researchers analyzed 105 eyes over 2-4 years, finding that eyes with AMD had significantly lower choroidal thickness (CT) and CVI than healthy eyes, with exudative AMD experiencing the most rapid thinning.
  • - The findings suggest that measuring CT and CVI could be useful for evaluating and predicting AMD progression, particularly in differentiating the severity of the disease.

Article Abstract

Introduction: The aim of the study was to investigate the rate of choroidal thinning and Choroidal Vascularity Index (CVI) changes over time in eyes with different stages of age-related macular degeneration (AMD) and control eyes.

Methods: Retrospective longitudinal study of 105 eyes with different stages of AMD: non-advanced (n = 46), exudative (n = 28), central complete retinal pigment epithelium and outer retinal atrophy (cRORA) (n = 5) and healthy eyes (n = 26). We evaluated choroidal thickness (CT) and CVI at baseline and during 2-4 years of follow-up. After adjustment for age and sex, we estimated the rate of change per year of CT and CVI in each group. We also performed logistic regression to analyze the relationship between baseline CT and CVI with AMD progression.

Results: The mean age of the included patients was 77.1 years with a mean follow-up of 3.36 years. Healthy eyes had higher baseline CT and CVI values compared to eyes with AMD. Exudative AMD showed a significant annual decrease in subfoveal CT (-5.1% per year vs. -3.5% in controls) and in the temporal and nasal sectors (-5.3% and -6.3%). CVI decreased during follow-up in all study groups, most in eyes with central cRORA (-1.09% per year).

Conclusion: CVI and CT values are reduced in eyes with AMD compared to healthy eyes. Eyes with exudative AMD have the highest annual rate of choroidal thinning, while CVI decreases most in eyes with central cRORA. CT and CVI may aid in a further stratification of AMD progression risk.

Download full-text PDF

Source
http://dx.doi.org/10.1159/000541481DOI Listing

Publication Analysis

Top Keywords

healthy eyes
12
eyes
10
cvi
9
choroidal thickness
8
choroidal vascularity
8
age-related macular
8
macular degeneration
8
rate choroidal
8
choroidal thinning
8
eyes stages
8

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!