AI Article Synopsis
- Indolent lymphomas often experience histological transformation (HT), which can worsen prognosis and complicate treatment.
- A case of splenic marginal zone lymphoma (SMZL) with an MYD88 mutation transformed into diffuse large B-cell lymphoma (DLBCL), revealing new genetic abnormalities.
- The significance of the MYD88 gene in SMZL remains uncertain, highlighting the need for more research on similar cases to better understand its role.
Article Abstract
In indolent lymphomas, histological transformation (HT) often results in a poor prognosis and presents a significant challenge in the management of these lymphomas. Previous studies have indicated that MYD88 mutations are associated with transformation in certain haematologic malignancies. We report a rare case of splenic marginal zone lymphoma (SMZL) harbouring an MYD88 mutation, which was transformed into diffuse large B-cell lymphoma (DLBCL) and accompanied by newly emerging genetic abnormalities. The role of the MYD88 gene in SMZL is currently unclear. Through this case, we reviewed relevant studies, which indicated that MYD88 mutations, along with other genetic anomalies, may play a significant role in this process. In the future, it is essential to collect more of these rare cases for further research.
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| http://dx.doi.org/10.1007/s00277-024-06080-5 | DOI Listing |
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