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A gut commensal protozoan determines respiratory disease outcomes by shaping pulmonary immunity.
Cell
December 2024
Department of Immunology, University of Toronto, Toronto, ON, Canada. Electronic address:
The underlying mechanisms used by the intestinal microbiota to shape disease outcomes of the host are poorly understood. Here, we show that the gut commensal protozoan, Tritrichomonas musculis (T.mu), remotely shapes the lung immune landscape to facilitate perivascular shielding of the airways by eosinophils.
View Article and Find Full Text PDFTuberculosis (TB) is an infectious disease caused by bacteria, which is more prevalent among immunocompromised individuals. According to the distribution of affected organs, this infection can be categorized as either pulmonary or extrapulmonary TB. Immunodeficiency states resulting from rheumatological disorders and the use of immunosuppressive medications, such as in Behçet's disease (BD), are potential predisposing factors for TB, particularly in cases involving multiple organs.
View Article and Find Full Text PDFIntestinal tuberculosis complicated with perforation in an immunocompetent patient: Case report and review of the literature.
Heliyon
October 2024
University of Tunis El Manar Faculty of Medicine of Tunis, Department of General Surgery, Trauma Center Ben Arous, Tunisia.
Introduction: Intestinal tuberculosis (ITB), a rare yet severe manifestation of infection, poses significant diagnostic and therapeutic challenges due to its nonspecific clinical presentation. Perforation, a life-threatening complication, necessitates prompt surgical intervention and effective antituberculous therapy.
Case Presentation: This case study highlights a 41-year-old immunocompetent male who presented with fever, abdominal pain, vomiting, and significant weight loss.
Prevalence of bovine paratuberculosis in Chinese cattle populations: a meta-analysis.
Front Cell Infect Microbiol
December 2024
Anhui Province Key Laboratory of Animal Nutritional Regulation and Health, Anhui Science and Technology University, Fengyang, China.
Background: Bovine paratuberculosis is a chronic infectious disease of ruminants primarily caused by (MAP). It is essentially a chronic granulomatous enteritis characterized by intractable diarrhea, progressive lethargy, and thickening of the intestinal mucosa with the formation of crumpled pouches. Bovine paratuberculosis not only adversely affects milk production and the quality of dairy products but also poses a significant threat to the economic development of dairy farming and human food security.
View Article and Find Full Text PDFParatuberculosis in South American camelids: two independent cases in alpacas in Germany.
BMC Vet Res
December 2024
Chemical and Veterinary Investigation Office Westphalia, Arnsberg, Germany.
Background: Paratuberculosis, caused by Mycobacterium avium subspecies paratuberculosis (MAP), is a chronic granulomatous enteritis that affects domestic and wild ruminants and camelids. The disease has rarely been reported in alpacas in Germany. This publication describes epidemiologically independent cases of paratuberculosis in two alpacas in Germany.
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