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Allergic Reactivity and Memory Occur Independently of Sequential Switching Through IgG1.
Allergy
January 2025
Schroeder Allergy and Immunology Research Institute, Department of Medicine, Faculty of Health Sciences, McMaster University, Hamilton, Canada.
Allergic reactions to foods are primarily driven by allergen-binding immunoglobulin (Ig)E antibodies. IgE-expressing cells can be generated through direct switching from IgM to IgE or a sequential class switching pathway where activated B cells first switch to an intermediary isotype, most frequently IgG1, and then to IgE. It has been proposed that sequential class switch recombination is involved in augmenting the severity of allergic reactions, generating high affinity IgE, differentiation of IgE plasma cells, and in holding the memory of IgE responses.
View Article and Find Full Text PDFThe Minimum Dietary Diversity For Women Indicator Can Be Extended To Children And Adolescents aged 4-15 Years As A Proxy Population Indicator For Good Micronutrient Adequacy Of Diets In Low- and Middle-Income Countries.
Curr Dev Nutr
January 2025
International Food Policy Research Institute (IFPRI), Washington, DC, United States.
Background: The response to the global call for more data on children's and adolescents' diets and nutrition is limited by the lack of straightforward practical indicators to track their diet quality. On the basis of a food group score compiled from 10 food groups (FGS-10), the minimum dietary diversity for women, calculated as FGS-10 ≥ 5, is a validated proxy population indicator for better micronutrient intake adequacy for adult women in low- and middle-income countries (LMICs).
Objectives: This study aims to validate FGS-10 and its related cutoffs against micronutrient intake adequacy in 4-15-y-old children/adolescents in LMICs.
Noradrenergic suppression to reduce electroencephalographic arousal after intubation: a randomised, placebo-controlled trial.
BJA Open
March 2025
Department of Anaesthetics, Royal Prince Alfred Hospital, Sydney, NSW, Australia.
Background: Intraoperative awareness, without explicit recall, occurs after induction of anaesthesia in approximately 10% of persons under 40 yr of age. Most anaesthetic agents minimally suppress the noradrenergic system. We hypothesised that addition of dexmedetomidine, which suppresses noradrenergic activity, may reduce encephalographic (EEG) arousal in response to tracheal intubation; such an effect would lay the foundation for future studies of dexmedetomidine in reducing intraoperative awareness.
View Article and Find Full Text PDFA Convolutional Neural Network Using Anterior Segment Photos for Infectious Keratitis Identification.
Clin Ophthalmol
January 2025
Center of Excellence for Cornea and Stem Cell Transplantation, Department of Ophthalmology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Purpose: To develop a comprehensively deep learning algorithm to differentiate between bacterial keratitis, fungal keratitis, non-infectious corneal lesions, and normal corneas.
Methods: This retrospective study collected slit-lamp photos of patients with bacterial keratitis, fungal keratitis, non-infectious corneal lesions, and normal cornea. Causative organisms of infectious keratitis were identified by either positive culture or clinical response to single treatment.
Development of novel patient-reported outcome instruments to assess atopic dermatitis-associated dyspigmentation and xerosis in patients with skin of colour.
Br J Dermatol
January 2025
Regeneron Pharmaceuticals Inc., Tarrytown, NY, USA.
Background: The prevalence and burden of atopic dermatitis (AD) are disproportionately high in individuals with skin of colour (SOC). Previous research shows that risk for xerosis and/or dyspigmentation is heightened in this population and may be more bothersome. However, there are no patient-reported instruments developed specifically for these disease sequelae in patients with SOC.
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