Using a protein scaffold covalently functionalised with a thiamine-inspired N-heterocyclic carbene (NHC), we created an artificial Stetterase (ArtiSt) which catalyses a stereoselective, intramolecular Stetter reaction. We demonstrate that ArtiSt functions under ambient conditions with low catalyst loading. Furthermore, activity can be increased >20 fold by altering the protein scaffold.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11533139 | PMC |
| http://dx.doi.org/10.1039/d4cc05182c | DOI Listing |
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