AI Article Synopsis
- Melanoma is a fast-growing skin cancer that poses significant challenges for treatment due to its ability to spread quickly and resist therapies, which is linked to its altered metabolism.
- The review investigates the molecular mechanisms behind these metabolic changes, including the Warburg effect and other factors like mitochondrial dysfunction and the tumor microenvironment, sourced from a comprehensive literature search.
- Understanding these metabolic processes is crucial for developing targeted treatments, as disrupting melanoma's metabolism could improve treatment options and patient outcomes in skin cancer care.
Article Abstract
Background: Melanoma, a highly aggressive skin cancer, is characterized by rapid progression and a high metastatic potential, presenting significant challenges in clinical oncology. A critical aspect of melanoma biology is its metabolic reprogramming, which supports tumor growth, survival, and therapeutic resistance.
Objective: This review aims to explore the key molecular mechanisms driving metabolic alterations in melanoma and their implications for developing therapeutic strategies.
Methods: A Pubmed search was conducted to analyze literature discussing key mechanisms of the Warburg effect, mitochondrial dysfunction, enhanced lipid metabolism, epigenetic modifications, and the tumor microenvironment.
Results: Metabolic reprogramming supports melanoma growth, proliferation, and survival. Understanding these complex metabolic dynamics provides valuable insights for developing targeted therapeutic strategies.
Conclusion: Potential therapeutic interventions aimed at disrupting melanoma metabolism highlight the promise of precision medicine in improving treatment outcomes in cutaneous oncology. By targeting metabolic vulnerabilities, novel treatment approaches could significantly enhance the clinical management and prognosis of melanoma.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11532834 | PMC |
| http://dx.doi.org/10.1002/cam4.70386 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!