Emergence of Daptomycin Nonsusceptibility and Treatment Failure in Patients With Bacteremia.

Open Forum Infect Dis

Division of Infectious Disease Therapeutics, Department of Microbiology and Infectious Diseases, Kobe University Graduate School of Medicine, Kobe, Japan.

Published: November 2024

AI Article Synopsis

  • - All 11 patients with bacteremia were treated with daptomycin and initially responded well, showing susceptibility to the drug.
  • - During treatment, daptomycin nonsusceptibility developed in 36% of the patients.
  • - Clinical failure occurred in 45% of the patients, highlighting significant challenges in effective treatment.

Article Abstract

We retrospectively reviewed patients with bacteremia treated with daptomycin. All 11 isolates were initially susceptible to daptomycin, but the emergence of daptomycin nonsusceptibility during treatment and clinical failure occurred in 36% and 45% of patients, respectively.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11528474PMC
http://dx.doi.org/10.1093/ofid/ofae610DOI Listing

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