This research study aims to illuminate Canadian musicians' portfolio careers across the cultural domains. Previous research has highlighted the career paths of music graduates directly after graduation, and other research has highlighted the experiences of well-known performers or pedagogues. However, little is known about music graduates who persist and establish careers in music. We interviewed twelve musicians working in a variety of Canadian cultural domains to understand their work and career paths. Their stories elucidate how artists balance income stability, artistic agency, creativity, and professional challenges to create impressive and fulfilling portfolios that enable them to use their music-based knowledge and skills in various ways. Findings from this study provide a more nuanced understanding of the scope and nature of music-related work in Canada and how artists integrate artistic and creative abilities with community needs and economic stability. These findings offer insights for emerging musicians and music graduates and have implications for educating and supporting artists who wish (or indeed need) to work across cultural domains.
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http://dx.doi.org/10.1177/02557614231191144 | DOI Listing |
Cell Biochem Biophys
December 2024
Department of Biomaterials/Osaka Dental University, 8-1, Kuzuhahanazono-cho, Osaka, 573-1121, Japan.
Elastic fibers of the internal and external elastic laminae maintain blood vessel shapes. Impairment of smooth muscle cell function leads to vascular disease development. F-box and WD-40 domain-containing protein 2 (FBXW2) is associated with elastic fibers and osteocalcin expression for bone regeneration in the periosteum.
View Article and Find Full Text PDFClin Transl Med
January 2025
Department of Gynecology, West China Second Hospital, Sichuan University, Chengdu, China.
Background: Hypoxia can affect the occurrence and development of inflammation in humans, but its effects on the disease progression of osteoarthritis (OA) remain unclear. Synovial macrophages play an essential role in the progression of arthritis. Specifically, the activation of the NOD-like receptor family pyrin domain containing 3 (NLRP3) in macrophages induces the secretion of a series of inflammatory factors, accelerating the progression of OA.
View Article and Find Full Text PDFGalvanic current has been emerging as a novel therapy to regenerate chronic tissue lesions, including musculoskeletal and dermatological lesions. Recently, the NLRP3 inflammasome and IL-1β release have been identified as a signaling pathway triggered upon galvanic current application. However, the parameters for the clinical application of galvanic current remain subjective to the experience of the facultative in charge.
View Article and Find Full Text PDFMenopause
January 2025
From the Department of Quality Control, Yuebei People's Hospital, Shantou University Medical College, Shaoguan, China.
Objective: The aim of this study was to modify the Chinese version of the Menopause Symptom Assessment Scale (MSAS) and evaluate its validity and reliability.
Methods: An expert panel from the gynecology and nursing domain determined items that should remain or be revised, and 30 participants were selected for the pilot study. A total of 255 women who met the criteria for inclusion were enrolled in the investigation.
Metabolites
December 2024
Department of Cell Biology and Physiology, Brigham Young University, Provo, UT 84602, USA.
Uric acid (UA), a metabolite of purine and fructose metabolism, is linked to inflammation and metabolic disorders, including gout and cardiovascular disease. Its pro-inflammatory effects are largely driven by the activation of the nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome, leading to increased cytokine production. Beta-hydroxybutyrate (BHB), a ketone produced during fasting or carbohydrate restriction, has been shown to reduce inflammation.
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