AI Article Synopsis
- Adverse Childhood Experiences (ACEs) are stressful events in early life, such as abuse and neglect, that can have lasting negative effects on health, particularly in women.
- Women who experience ACEs are more likely to develop obesity and cardiometabolic diseases compared to men.
- Research using rodent models shows that early life stress affects neuroendocrine systems differently in males and females, suggesting this may explain women's increased risk of obesity and metabolic disorders.
Article Abstract
Adverse Childhood Experiences (ACEs) refer to early life stress events, including abuse, neglect, and other psychosocial childhood traumas that can have long-lasting effects on a wide range of physiological functions. ACEs provoke sex-specific effects, whereas women have been shown to display a strong positive correlation with obesity and cardiometabolic disease. Notably, rodent models of chronic behavioral stress during postnatal life recapitulate several effects of ACEs in a sex-specific fashion. In this review, we will discuss the potential mechanisms uncovered by models of early life stress that may explain the greater susceptibility of females to obesity and metabolic risk compared with their male counterparts. We highlight the early life stress-induced neuroendocrine shaping of the adrenal-adipose tissue axis as a primary event conferring sex-dependent heightened sensitivity to obesity.
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Source |
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11527639 | PMC |
| http://dx.doi.org/10.3389/fendo.2024.1481923 | DOI Listing |
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