AI Article Synopsis
- The study assessed DANTE T1-SPACE imaging techniques for diagnosing optic neuritis and its correlation with clinical findings before and after treatment.
- Patients with optic neuritis or NA-AION underwent MR imaging and clinical evaluations at Kyoto University Hospital, with multiple specialists reviewing the scans.
- Results indicated that DANTE T1-SPACE had a higher sensitivity for detecting optic neuritis compared to other MRI sequences, while no significant differences were found for NA-AION diagnostics.
Article Abstract
Purpose: To evaluate the use of delay alternating with nutation for tailored excitation-prepared T1-weighted turbo spin echo (DANTE T1-SPACE) imaging for diagnosing optic neuritis and to analyze its correlation with clinical findings before and after treatment.
Patients And Methods: Patients diagnosed with optic neuritis or non-arteritic anterior ischemic optic neuropathy (NA-AION) were evaluated at the Ophthalmology Department of Kyoto University Hospital. All patients underwent magnetic resonance (MR) studies before treatment initiation and ophthalmic examinations before and after treatment. Three ophthalmologists independently reviewed the MR scans for abnormalities. The magnetic resonance imaging (MRI) assessments included post-contrast DANTE T1-SPACE, post-contrast volumetric interpolated breath-hold examination (VIBE), and short T1 inversion recovery (STIR) scans. The presence of abnormalities in each sequence was determined.
Results: Of 36 eyes from 30 patients, 21 eyes from 17 patients were diagnosed with optic neuritis, and 15 eyes from 13 patients were diagnosed with NA-AION. DANTE T1-SPACE sequences showed better sensitivity for detecting optic neuritis than STIR sequences (100% vs 67%, p = 0.009). VIBE images did not confirm enhancement of lesions in some cases with optic neuritis. No differences were observed among the sequences for NA-AION. Lesion length evaluated by DANTE T1-SPACE sequences was associated with circumpapillary retinal nerve fiber layer thickness at the initial visit, eye pain, and the time interval from symptom onset to MRI scan.
Conclusion: Contrast-enhanced DANTE T1-SPACE was better than other sequences of MRI for diagnosing optic neuritis.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11531292 | PMC |
| http://dx.doi.org/10.2147/EB.S474100 | DOI Listing |
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